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MB Sample ID: SA001264
| Local Sample ID: | 2924-fu18 |
| Subject ID: | SU000037 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Age Or Age Range: | 56-78 |
| Weight Or Weight Range: | Obese or Overweight |
| Gender: | Male, Female |
| Human Race: | Caucasian, African American |
| Human Trial Type: | Intervention |
| Species Group: | Human |
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Collection:
| Collection ID: | CO000020 |
| Collection Summary: | Urine samples (early morning [second morning void) after a 10-hour fast]) collected from 44 overweight or obese participants in the IDEA trial at baseline and at 18 months of follow-up were selected from two subgroups (n=22 each): a group that exhibited radiographic progression and an age, race, sex, and BMI matched group who did not progress. Progression was defined radiographically by a ≥ 0.7mm decrease in medial JSW from baseline to 18 months while non-progression was defined as a decrease in medial JSW of ≤0.35mm . All subjects experienced knee pain and had radiographic evidence of tibiofemoral OA. For those people who were assigned an intervention that included exercise, the 18-month samples were collected at least 24 hours after the last acute bout of exercise training. In addition sampling was postponed (1-2 weeks after recovery from symptoms) in the event of an acute respiratory, urinary tract, or other infection. Urine was aliquoted and stored in cryovials at -80°C. |
| Sample Type: | Urine |
| Collection Frequency: | Baseline and after 18 month (Follow up) |
| Volumeoramount Collected: | 1.8 mL of urine |
| Storage Conditions: | 80C. |
