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MB Sample ID: SA009298
| Local Sample ID: | ms1861-1 |
| Subject ID: | SU000187 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Species Group: | Human |
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Treatment:
| Treatment ID: | TR000194 |
| Treatment Summary: | Placebo|Metformin |
| Treatment Protocol Comments: | We previously reported the overall study design for the parent study [29]. The current report primarily examines the effect of three months of insulin sensitizer therapy on plasma concentrations of BCAA, AAA, and AA metabolites in overweight/obese adults with fasting hyperglycemia, defined as either impaired fasting glucose or untreated diabetes [29]. Briefly, 25 drug naïve, Northern European American participants with fasting blood glucose concentrations of 108180 mg/dL were randomized to receive either 45 mg of pioglitazone per day plus 1 g of metformin twice per day (n = 12) or placebo (n = 13) for 12 weeks. We chose metformin based on its proven effect on hepatic insulin sensitivity and pioglitazone based on its effect on peripheral insulin sensitivity. Current use of hypoglycemic medications excluded participants from the present study.|We previously reported the overall study design for the parent study [29]. The current report primarily examines the effect of three months of insulin sensitizer therapy on plasma concentrations of BCAA, AAA, and AA metabolites in overweight/obese adults with fasting hyperglycemia, defined as either impaired fasting glucose or untreated diabetes [29]. Briefly, 25 drug naïve, Northern European American participants with fasting blood glucose concentrations of 108180 mg/dL were randomized to receive either 45 mg of pioglitazone per day plus 1 g of metformin twice per day (n = 12) or placebo (n = 13) for 12 weeks. We chose metformin based on its proven effect on hepatic insulin sensitivity and pioglitazone based on its effect on peripheral insulin sensitivity. Current use of hypoglycemic medications excluded participants from the present study. |
