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MB Sample ID: SA096588
| Local Sample ID: | 88_1919_C_F_128_0 |
| Subject ID: | SU001407 |
| Subject Type: | Other |
| Subject Species: | Mus musculus |
| Taxonomy ID: | 10090 |
| Genotype Strain: | YAC128 and wildtype (WT) |
| Age Or Age Range: | 12 week and 32 week |
| Gender: | Male and female |
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Treatment:
| Treatment ID: | TR001422 |
| Treatment Summary: | This study utilized three Mn exposure paradigms: 1) a single subcutaneous exposure of either a 1% solution of MnCl2•4(H2O) in filtered MilliQ water at 50 mg/kg body weight or vehicle (filtered water), 2) a 1-week, and 3) 20-week chronic exposure. The 1-week exposure is a previously published week-long exposure protocol (intermittent injections given on days 0, 3 and 6, with sacrifice on day 7) known to elevate brain Mn levels1. The 20-week exposure is a twice weekly injection (Mondays and Thursdays) based on the estimated half-life of 3.5 days for Mn administered via this route and pilot work suggesting the absence of observable toxicity with this exposure paradigm (including no weight loss or physical signs of distress). |
| Treatment Compound: | Mn |
| Treatment Dose: | 0, 5, 15, 50 mg/kg body weight |
