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MB Sample ID: SA158405

Local Sample ID:negMSMSALL-SC-D3-IR_SA121_2
Subject ID:SU001781
Subject Type:Mammal
Subject Species:Mus musculus
Taxonomy ID:10090
Genotype Strain:C57BL/6J
Age Or Age Range:12-17 weeks
Gender:Female

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Treatment:

Treatment ID:TR001794
Treatment Summary:Forty female C57BL/6J mice (Jackson Laboratory, Bar Harbor, ME, USA), 12 weeks of age, were randomly split between two cohorts; Irradiated (IR) and Non-Irradiated (Non-IR) (n=20) and were used for all experiments. Two sub-lethal doses of cesium-137 (Cs-137) whole-body irradiation (2x 3 Gy; total of 6 Gy) with an exposure time of 3.72 minutes per mouse (total of 7.44 minutes) were administered 4 hours apart to the IR mice (n=20) on Day 0. Within each cohort, mice were sub-divided into treatment groups; Vehicle and Scl-Ab VI (25 mg/kg) (supplied by Amgen Inc/UCB Pharma) (n=10/per treatment). All mice were administered either a sterile phosphate buffered saline (PBS) vehicle control or Scl-Ab (25 mg/kg), once weekly via subcutaneous injections for a duration of 5 weeks, starting on Day 0. No adverse effects were observed after the administration of Scl-Ab. All experimental studies and procedures involving mice were performed in accordance with protocols approved by the governing Institutional Animal Care and Use Committee (IACUC). Additional Study Design and Drug Treatment information can be found in the Supplemental Material.
Treatment:Neutralizing antibodies to sclerostin (Scl-Ab)
Treatment Compound:Scl-Ab VI (supplied by Amgen Inc/UCB Pharma)
Treatment Route:subcutaneous injections
Treatment Dose:25 mg/kg
Treatment Doseduration:once weekly for 5 weeks
Treatment Vehicle:sterile phosphate buffered saline (PBS) vehicle control
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