Summary of Study ST002194

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001398. The data can be accessed directly via it's Project DOI: 10.21228/M8141Z This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002194
Study TitleMetabolic profiling at COVID-19 onset shows disease severity and sex-specific dysregulation
Study SummaryIn this study CE-MS and GC-MS based metabolomics was used to analyze COVID-19 disease. In total, 144 individuals classified as healthy, asymptomatic/mils, moderate and severe according to the highest COVID-19 severity status, were analyzed.
Institute
CEMBIO
Last NameBarbas
First NameCoral
AddressCEU Universities, Urbanización Montepríncipe
Emailcbarbas@ceu.es
Phone+34 913724700
Submit Date2022-06-09
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailGC/LC-MS
Release Date2022-06-17
Release Version1
Coral Barbas Coral Barbas
https://dx.doi.org/10.21228/M8141Z
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN003591 AN003592
Analysis type MS MS
Chromatography type Other GC
Chromatography system Agilent 7100 CE 8890
Column silica capillary (100 cm; inner diameter, 50 µm, Agilent Technologies) Agilent DB5-MS (30m x 0.25mm, 0.25um)
MS Type ESI EI
MS instrument type TOF Single quadrupole
MS instrument name Agilent CE-TOFMS Agilent 5977B
Ion Mode POSITIVE UNSPECIFIED
Units Peak Area Corrected areas

Chromatography:

Chromatography ID:CH002653
Chromatography Summary:Metabolite separation was performed in a fused silica capillary (100 cm; inner diameter, 50 µm, Agilent Technologies). Before each analysis, background electrolyte (BFE) (0.8 M formic acid solution in 10 % MeOH; v/v) was flushed for 5 min (950 mbar). Samples injections were performed over 50 s at 50 mbar and BGE was injected after each injection for 10 s at 100 mbar to improve reproducibility. The separation was carried out with an internal pressure of 25 mbar and 30 kV voltage with a total analytical run time of 35 min.
Methods Filename:Sample_Analysis.pdf
Instrument Name:Agilent 7100 CE
Column Name:silica capillary (100 cm; inner diameter, 50 µm, Agilent Technologies)
Chromatography Type:Other
  
Chromatography ID:CH002654
Chromatography Summary:The flow rate of helium carrier gas was constant at 1.1359 mL/min and the injector temperature was set at 250 °C. The lock of the retention time (RTL) relative to the internal standard (methyl stearate) peak at 19.66 min was performed. The oven temperature gradient was initially set at 60 °C and was maintained for 1 min. Then it was raised by 10 °C/min until it reached 325 °C, and then was held at this temperature for 10 min before cooling down. The total analysis run time was 37.5 min.
Methods Filename:Sample_Analysis.pdf
Instrument Name:8890
Column Name:Agilent DB5-MS (30m x 0.25mm, 0.25um)
Chromatography Type:GC
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