Summary of Study ST000782
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000568. The data can be accessed directly via it's Project DOI: 10.21228/M87T1Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST000782 |
| Study Title | Nuclear magnetic resonance-based metabolomics approach to evaluate the prevention effect of Camellia nitidissima Chi on colitis-associated carcinogenesis |
| Study Type | Original Research |
| Study Summary | Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, occurring in the colon or rectum portion of large intestine. With marked antioxidant, anti-inflammation and anti- tumor activities, Camellia nitidissima Chi has been used as an effective treatment of cancer. The azoxymethane/dextran sodium sulfate (AOM/DSS) induced CRC mice model was established and the prevention effect of Camellia nitidissima Chi extracts on the evolving of CRC was evaluated by gross examination, histopathological inspection, serum biochemistry analysis, combined with nuclear magnetic resonance (NMR)-based metabolomics and correlation network analysis. The results showed that Camellia nitidissima Chi extracts could significantly inhibit AOM/DSS induced CRC, relieve the colonic pathology and ameliorate the serum biochemistry, and could significantly reverse the disturbed metabolism towards the normal state. Moreover, the butanol fraction showed a better efficiency than the water-soluble fraction of Camellia nitidissima Chi. The study pave the way for further development of Camellia nitidissima Chi extracts as a potent CRC inhibitor. In this work, rats were divided into control group, carcinoma group, and two drug groups of JHC and CNC. The acronyms JHC means the water-soluble fraction of Camellia nitidissima Chi. The acronyms CNC means the butanol fraction of Camellia nitidissima Chi. |
| Institute | Nanjing University of Science & Technology |
| Last Name | Li |
| First Name | Minghui |
| Address | 200 Xiaolingwei Street, Nanjing 210094, China |
| cpu_lmh@126.com | |
| Phone | +86 15952052370 |
| Submit Date | 2017-05-21 |
| Analysis Type Detail | NMR |
| Release Date | 2017-10-03 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Collection:
| Collection ID: | CO000804 |
| Collection Summary: | Briefly, tissues of intestines, kidneys and spleens weighting about 200 mg, 200 mg and 110 mg were weighted, homogenized with an icy cold solvent (the ratio of tissue weight to 50 % acetonitrile volume was 1: 5, w/v), vortexed, and centrifuged for 10 min at 12,000 g and 4 °C. The supernatant was transferred into fresh Eppendorf tube and was then frozen and lyophilized to dryness on a vacuum concentrator. The dried samples were stored at -80 °C until use. |
| Sample Type: | Intestine |
