Summary of Study ST001022
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000683. The data can be accessed directly via it's Project DOI: 10.21228/M8D11B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001022 |
| Study Title | Characterization of metabolomics profile changes during development of post-traumatic epilepsy in Rat Brain Tissue (part-III) |
| Study Summary | Characterize the metabolomics profile changes during progression of the transition from traumatic brain injury (TBI) to post-traumatic epilepsy (PTE). To do so, three experiments will be performed. PTE animal model will be developed using ferrous chloride injections. Metabolomics profile changes will be obtained before TBI, after TBI, and after PTE development These temporal changes in metabolomics profile during the course of PTE development will be collected. We will also collect cerebrospinal fluid (CSF) at each time point. In addition, we will collect the brain tissue from the center of injury, around the injury, and from the non-injured area for mass spectrometry. In this study, the rat brain tissue at end of study is analyzed. |
| Institute | Mayo Clinic |
| Last Name | Su-youne |
| First Name | Chang |
| Address | 200 1st Street SW Rochester, MN 55905, USA |
| Chang.SuYoune@mayo.edu | |
| Phone | 1-507-293-0511 |
| Submit Date | 2018-07-17 |
| Analysis Type Detail | LC-MS |
| Release Date | 2020-07-15 |
| Release Version | 1 |
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Collection:
| Collection ID: | CO001055 |
| Collection Summary: | Rats will either be controls, injected with saline, or injected with ferrous chloride to influence PTE. Also one of the ferrous chloride treated rats was repeated (R_no_cx, R_no_hp, R_inj_cx, R_inj_hp). Study Groupings: C_no_cx = control, no injections, cortex tissue C_no_hp = control, no injections, hippocampus tissue S_no_cx = saline treated, cortex tissue not near injection site S_no_hp = saline treated, hippocampus tissue not near injection site S_inj_cx = saline treated, cortex tissue at injection site S_inj_hp = saline treated, hippocampus tissue at injection site F_no_cx = ferrous chloride treated, cortex tissue not near injection site F_no_hp = ferrou chloride treated, hippocampus tissue not near injection site F_inj_cx = ferrous chloride treated, cortex tissue at injection site F_inj_hp = ferrous chloride treated, hippocampus tissue at injection site Experimental Flow Day0: baseline pre TBI. Blood and CSF collected Day1: Surgery for TBI. Injections of Ferrous Cloride or Saline Day2: CSF collected Weeks1-3: montoring to determine PTE starting point. Blood and CSF collected 1 Month: montoring of PTE. Blood and CSF collected 2 Month: Animal is euthanized and blood, CSF, and tissue harvested |
| Sample Type: | Brain |
