Summary of Study ST001317
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000894. The data can be accessed directly via it's Project DOI: 10.21228/M84D6J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001317 |
Study Title | Dynamics of Exposure, Phthalates, and Asthma in a Randomized Trial (DEPART) |
Study Type | CHEAR Study |
Study Summary | Project will investigate relationships between phthalate exposure, pediatric asthma health, and underlying biological pathways of toxicity among a rural, underserved Latino population located in Yakima Valley, WA. DEPART will benefit from the original study’s (HAPI’s) robust longitudinal repeat-measure design and community-engaged framework. DEPART will add new measurements including concentrations of urinary phthalate monoester metabolites and biomarkers of oxidative stress to better characterize exposure-response associations. This project’s primary goal is to deepen the understanding of pathophysiological phenomena underlying exposure-response relationships between phthalates and asthma health. Our specific aims are: (1) Characterize associations between urinary phthalate metabolite concentrations and short-term asthma morbidity, and (2) Determine individual relationships between urinary phthalate metabolite concentrations, short-term asthma morbidity, and biomarkers for oxidative stress to assess the potential for a mediating effect by oxidative stress. Covariates of interest will include atopic status, randomized intervention grouping, and the caregiver psychosocial stress assessment. |
Institute | Icahn School of Medicine at Mount Sinai |
Department | Department of Environmental Medicine and Public Health |
Laboratory | Mount Sinai CHEAR Untargeted Laboratory Hub |
Last Name | Walker |
First Name | Douglas |
Address | Atran Building RM AB3-39, 1428 Madison Ave |
douglas.walker@mssm.edu | |
Phone | 212-241-9891 |
Submit Date | 2020-02-05 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Chear Study | Yes |
Analysis Type Detail | LC-MS |
Release Date | 2021-08-31 |
Release Version | 1 |
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Collection:
Collection ID: | CO001386 |
Collection Summary: | All study participants provide 4 individual urine samples corresponding to 4 unique time points: 2 pre intervention and 2 post-intervention samples. The first of these 4 urine samples are from an afternoon/evening clinic visit at baseline, and the remaining 3 urine samples are first morning voids. All materials for urine sample collection are phthalate-free. All have been stored in a -20 freezer in the field, then transfered on dry ice to UW -20 freezer equipped with temperature alarms. Samples have not yet been thawed. |
Sample Type: | Urine |
Storage Conditions: | -20℃ |