Summary of Study ST000215

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000169. The data can be accessed directly via it's Project DOI: 10.21228/M8N88K This work is supported by NIH grant, U2C- DK119886.


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Study IDST000215
Study TitleLiver and Plasma metaboites for 13C-glucose load in wild type, LIRKO GTT 1 mice
Study Type13C mass isotopomer analysis (flux studies)
Study SummaryMice were fasted for 18 hr overnight then sacrificed or treated with 13C-U-glucose (2 g/kg ip) and sacrificed 1 hr later by decapitation and liver was immediately freeze-clamped and stored in liquid N2 and then at -80 C. Wild type (IR and IR/FoxO1 floxed) mice were sacrificed after fasting and 1 hr post-glucose treatment. Liver-specific insulin receptor knockout (LIRKO) and insulin receptor/FoxO1 double knockout (LIRFKO) mice were sacrificed 1 hr post glucose treatment.
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Submit Date2015-06-12
Num Groups5
Total Subjects40
Raw Data AvailableYes
Raw Data File Type(s)d
Uploaded File Size2.5 G
Analysis Type DetailGC/LC-MS
Release Date2015-12-28
Release Version1
Maureen Kachman Maureen Kachman application/zip

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Subject type: Animal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id treatment Strain
SA010568S00013145glucose IRF floxed
SA010565S00013143glucose IR floxed
SA010566S00013144glucose IR floxed
SA010567S00013142glucose IR floxed
SA010569S00013152glucose LIRFKO
SA010570S00013154glucose LIRFKO
SA010571S00013153glucose LIRFKO
SA010572S00013155glucose LIRFKO
SA010573S00013149glucose LIRKO
SA010574S00013150glucose LIRKO
SA010575S00013151glucose LIRKO
SA010576S00013148glucose LIRKO
SA010577S00013147glucose LIRKO
SA010578S00013146glucose LIRKO
SA010579S00013139none IR floxed
SA010580S00013141none IR floxed
SA010581S00013138none IR floxed
SA010582S00013137none IR floxed
SA010583S00013136none IR floxed
SA010584S00013140none IR floxed
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