Summary of Study ST000483

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000367. The data can be accessed directly via it's Project DOI: 10.21228/M8MC7X This work is supported by NIH grant, U2C- DK119886.

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Study IDST000483
Study TitleAmino Acid Quantifcation of obese patients on a 16 week caloric restriction from Plasma
Study Typetimecourse, quantitative measurements of amino acid
Study SummaryCaloric restriction (CR) improves insulin sensitivity and reduces the incidence of diabetes in obese individuals. The underlying mechanisms whereby CR improves insulin sensitivity are not clear. We evaluated the effect of 16 weeks of CR on whole-body insulin sensitivity by pancreatic clamp before and after CR in 11 obese participants (BMI = 35 kg/m2) compared with 9 matched control subjects (BMI = 34 kg/m2). Compared with the control subjects, CR increased the glucose infusion rate needed to maintain euglycemia during hyperinsulinemia, indicating enhancement of peripheral insulin sensitivity. This improvement in insulin sensitivity was not accompanied by changes in skeletal muscle mitochondrial oxidative capacity or oxidant emissions, nor were there changes in skeletal muscle ceramide, diacylglycerol, or amino acid metabolite levels. However, CR lowered insulin-stimulated thioredoxin-interacting protein (TXNIP) levels and enhanced nonoxidative glucose disposal. These results support a role for TXNIP in mediating the improvement in peripheral insulin sensitivity after CR.
Institute
Mayo Clinic
DepartmentEndocrinology
LaboratoryMayo Clinic Metabolomics Resource Core
Last NameNair
First NameSreekumaran
Address200 First Street SW, Rochester, MN 55905
EmailNair.K@mayo.edu
Phone507-285-2415
Submit Date2016-09-23
PublicationsMechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults. DOI: 10.2337/db15-0675
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2016-12-22
Release Version1
Sreekumaran Nair Sreekumaran Nair
https://dx.doi.org/10.21228/M8MC7X
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Animal; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id time (mins) Category
SA024582ms5361-111 Caloric Restriction
SA024583ms5361-331 Caloric Restriction
SA024584ms5361-311 Caloric Restriction
SA024585ms5361-231 Caloric Restriction
SA024586ms5361-11 Caloric Restriction
SA024587ms5361-191 Caloric Restriction
SA024588ms5361-131 Caloric Restriction
SA024589ms5361-91 Caloric Restriction
SA024590ms5361-51 Caloric Restriction
SA024591ms5361-31 Caloric Restriction
SA024592ms5361-71 Caloric Restriction
SA024593ms5361-391 Control
SA024594ms5361-251 Control
SA024595ms5361-291 Control
SA024596ms5361-371 Control
SA024597ms5361-351 Control
SA024598ms5361-271 Control
SA024599ms5361-211 Control
SA024600ms5361-171 Control
SA024601ms5361-151 Control
SA024602ms5361-122 Caloric Restriction
SA024603ms5361-202 Caloric Restriction
SA024604ms5361-322 Caloric Restriction
SA024605ms5361-102 Caloric Restriction
SA024606ms5361-82 Caloric Restriction
SA024607ms5361-342 Caloric Restriction
SA024608ms5361-142 Caloric Restriction
SA024609ms5361-62 Caloric Restriction
SA024610ms5361-242 Caloric Restriction
SA024611ms5361-22 Caloric Restriction
SA024612ms5361-42 Caloric Restriction
SA024613ms5361-382 Control
SA024614ms5361-362 Control
SA024615ms5361-402 Control
SA024616ms5361-302 Control
SA024617ms5361-182 Control
SA024618ms5361-222 Control
SA024619ms5361-162 Control
SA024620ms5361-262 Control
SA024621ms5361-282 Control
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