Summary of Study ST000530

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000389. The data can be accessed directly via it's Project DOI: 10.21228/M8S02S This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000530
Study TitleEffects of herb DG and KK01 on Type 2 Diabetes Mellitus (T2DM) through Lipidomics
Study TypeLC-MS lipidomics
Study SummaryAccording to the results in animal test, KK01 is effective in controlling blood glucose increase with comparable effect as metformin and rosiglitazone. This study will conduct lipid profile comparison for serum samples generated from the animal tests. The comparison will be based on the following groups: 1) db/db mice + DG-high dose; 2) db/db mice +DG-low dose; 3) db/db mice + KK01-high dose; 4) db/db mice + KK01-low dose; 5) db/db mice + metformin; 6) db/db mice + rosiglitazone; 7) db/db mice + saline (disease model); and 8) wild type mice + saline (healthy model). The determined lipid marker(s) will be applied to elucidate the drug target(s) and mechanisms of DG and KK01. Furthermore, comparison of target(s) between KK01 and the first line drugs in diabetic treatment, e.g., metformin and rosiglitazone, will facilitate the finding of featured pathway(s) of KK01 differentiated from the established drugs. Comparison of drug target(s) between KK01 and DG can help to understand the synergistic effects of multiple constituents in the herb.
Institute
University of North Carolina
DepartmentSystems and Translational Sciences
LaboratorySumner Lab
Last NameSumner
First NameSusan
AddressEastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081
Emailsusan_sumner@unc.edu
Phone704-250-5066
Submit Date2016-12-30
Num Groups10
Total Subjects93 samples for positive mode and 80 samples for negative mode
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2018-02-07
Release Version1
Susan Sumner Susan Sumner
https://dx.doi.org/10.21228/M8S02S
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Serum; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Gene type Phenotypic grouping and treaments
SA027878S_53C57BLKsJ-db/db Group1, DG extract high dose
SA027879S_60C57BLKsJ-db/db Group1, DG extract high dose
SA027880S_47C57BLKsJ-db/db Group1, DG extract high dose
SA027881S_56C57BLKsJ-db/db Group1, DG extract high dose
SA027882S_67C57BLKsJ-db/db Group1, DG extract high dose
SA027883S_7C57BLKsJ-db/db Group1, DG extract high dose
SA027884S_19C57BLKsJ-db/db Group1, DG extract high dose
SA027875S_28C57BLKsJ-db/db Group1, DG extract high dose
SA027876S_34C57BLKsJ-db/db Group1, DG extract high dose
SA027877S_42C57BLKsJ-db/db Group1, DG extract high dose
SA027813S_3C57BLKsJ-db/db Group 2, DG extract low dose
SA027814S_36C57BLKsJ-db/db Group 2, DG extract low dose
SA027815S_57C57BLKsJ-db/db Group 2, DG extract low dose
SA027816S_38C57BLKsJ-db/db Group 2, DG extract low dose
SA027817S_54C57BLKsJ-db/db Group 2, DG extract low dose
SA027818S_25C57BLKsJ-db/db Group 2, DG extract low dose
SA027819S_77C57BLKsJ-db/db Group 2, DG extract low dose
SA027820S_4C57BLKsJ-db/db Group 2, DG extract low dose
SA027821S_16C57BLKsJ-db/db Group 2, DG extract low dose
SA027822S_73C57BLKsJ-db/db Group 2, DG extract low dose
SA027823S_33C57BLKsJ-db/db Group 3, KK 01 high dose
SA027824S_76C57BLKsJ-db/db Group 3, KK 01 high dose
SA027825S_51C57BLKsJ-db/db Group 3, KK 01 high dose
SA027826S_5C57BLKsJ-db/db Group 3, KK 01 high dose
SA027827S_61C57BLKsJ-db/db Group 3, KK 01 high dose
SA027828S_48C57BLKsJ-db/db Group 3, KK 01 high dose
SA027829S_20C57BLKsJ-db/db Group 3, KK 01 high dose
SA027830S_15C57BLKsJ-db/db Group 3, KK 01 high dose
SA027831S_59C57BLKsJ-db/db Group 3, KK 01 high dose
SA027832S_66C57BLKsJ-db/db Group 3, KK 01 high dose
SA027833S_79C57BLKsJ-db/db Group 4, KK 01 low dose (i.p.)
SA027834S_23C57BLKsJ-db/db Group 4, KK 01 low dose (i.p.)
SA027835S_14C57BLKsJ-db/db Group 4, KK 01 low dose (i.p.)
SA027836S_82C57BLKsJ-db/db Group 4, KK 01 low dose (i.p.)
SA027837S_50C57BLKsJ-db/db Group 4, KK 01 low dose (i.p.)
SA027838S_29C57BLKsJ-db/db Group 4, KK 01 low dose (i.p.)
SA027839S_37C57BLKsJ-db/db Group 4, KK 01 low dose (i.p.)
SA027840S_43C57BLKsJ-db/db Group 4, KK 01 low dose (i.p.)
SA027841S_39C57BLKsJ-db/db Group 4, KK 01 low dose (i.p.)
SA027842S_12C57BLKsJ-db/db Group 4, KK 01 low dose (i.p.)
SA027843S_44C57BLKsJ-db/db Group 5, metformin
SA027844S_71C57BLKsJ-db/db Group 5, metformin
SA027845S_13C57BLKsJ-db/db Group 5, metformin
SA027846S_75C57BLKsJ-db/db Group 5, metformin
SA027847S_58C57BLKsJ-db/db Group 5, metformin
SA027848S_49C57BLKsJ-db/db Group 5, metformin
SA027849S_1C57BLKsJ-db/db Group 5, metformin
SA027850S_74C57BLKsJ-db/db Group 5, metformin
SA027851S_8C57BLKsJ-db/db Group 5, metformin
SA027852S_46C57BLKsJ-db/db Group 6, rosiglitazone
SA027853S_18C57BLKsJ-db/db Group 6, rosiglitazone
SA027854S_52C57BLKsJ-db/db Group 6, rosiglitazone
SA027855S_2C57BLKsJ-db/db Group 6, rosiglitazone
SA027856S_45C57BLKsJ-db/db Group 6, rosiglitazone
SA027857S_69C57BLKsJ-db/db Group 6, rosiglitazone
SA027858S_21C57BLKsJ-db/db Group 6, rosiglitazone
SA027859S_32C57BLKsJ-db/db Group 6, rosiglitazone
SA027860S_65C57BLKsJ-db/db Group 6, rosiglitazone
SA027861S_72C57BLKsJ-db/db Group 6, rosiglitazone
SA027862S_68C57BLKsJ-db/db Group 7, saline
SA027863S_70C57BLKsJ-db/db Group 7, saline
SA027864S_22C57BLKsJ-db/db Group 7, saline
SA027865S_41C57BLKsJ-db/db Group 7, saline
SA027866S_24C57BLKsJ-db/db Group 7, saline
SA027867S_64C57BLKsJ-db/db Group 7, saline
SA027868S_40C57BLKsJ-db/db Group 7, saline
SA027869S_27C57BLKsJ-db/db Group 7, saline
SA027870S_62C57BLKsJ-db/db Group 7, saline
SA027871S_35C57BLKsJ-db/db Group 8, saline
SA027872S_81C57BLKsJ-db/db Group 9, saline (i.p.)
SA027873S_83C57BLKsJ-db/db Group 9, saline (i.p.)
SA027874S_10C57BLKsJ-db/db Group 9, saline (i.p.)
SA027803S_55C57BLKsJ (WT) Group 8, saline
SA027804S_9C57BLKsJ (WT) Group 8, saline
SA027805S_17C57BLKsJ (WT) Group 8, saline
SA027806S_30C57BLKsJ (WT) Group 8, saline
SA027807S_78C57BLKsJ (WT) Group 8, saline
SA027808S_11C57BLKsJ (WT) Group 8, saline
SA027809S_26C57BLKsJ (WT) Group 8, saline
SA027810S_80C57BLKsJ (WT) Group 8, saline
SA027811S_63C57BLKsJ (WT) Group 8, saline
SA027812S_6C57BLKsJ (WT) Group 8, saline
SA027885P_8Pool serum from Sigma -
SA027886P_9Pool serum from Sigma -
SA027887P_11Pool serum from Sigma -
SA027888P_7Pool serum from Sigma -
SA027889P_10Pool serum from Sigma -
SA027890P_2Pool serum from Sigma -
SA027891P_1Pool serum from Sigma -
SA027892P_3Pool serum from Sigma -
SA027893P_4Pool serum from Sigma -
SA027894P_5Pool serum from Sigma -
SA027895P_6Pool serum from Sigma -
Showing results 1 to 93 of 93
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