Summary of Study ST000633

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000457. The data can be accessed directly via it's Project DOI: 10.21228/M8060Z This work is supported by NIH grant, U2C- DK119886.

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Study IDST000633
Study TitleNeuromodulator Metabolites of Dietary Salt Effects on Blood Pressure in Rat Urine (part VI)
Study SummaryWe propose to analyze kidney tissue extract and urine samples from SS and SS.Fh1+ transgenic rats in addition to the analysis of urine samples from the DASH2 trial. The analysis of the rat samples will be highly valuable for several reasons. First, it will to take the findings in human subjects back to animal models and prepare us for further mechanistic studies. We hypothesize at least some of the effects of dietary salt intake on metabolite profiles in human will be recapitulated or altered in the SS rat. If this is confirmed, we will have a highly informative animal model ready for mechanistic studies in which we can investigate the functional contribution of specific metabolites to hypertension and the mechanisms involved. Second, the rat study will allow us to take advantage of a new and unique transgenic SS.Fh1+ model that we recently developed that overexpresses fumarase (Fh1) on the genetic background of the SS rat. Fumarase is a TCA cycle enzyme previously implicated in salt-induced hypertension in SS rats.
Institute
Mayo Clinic
Last NameLiang
First NameMingyu
AddressMedical College of Wisconsin 8701 Watertown Plank Road Milwaukee, WI 53226
Emailmliang@mcw.edu
Phone414-955-8539
Submit Date2017-06-23
Analysis Type DetailLC-MS
Release Date2019-07-17
Release Version1
Mingyu Liang Mingyu Liang
https://dx.doi.org/10.21228/M8060Z
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Rat; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id local_sample_id Time point
SA035417ms5954-157 day HS
SA035418ms5954-147 day HS
SA035419ms5954-137 day HS
SA035420ms5954-167 day HS
SA035421ms5954-297 day HS
SA035422ms5954-277 day HS
SA035423ms5954-287 day HS
SA035424ms5954-127 day HS
SA035425ms5954-307 day HS
SA035426ms5954-117 day HS
SA035427ms5954-347 day HS
SA035428ms5954-357 day HS
SA035429ms5954-367 day HS
SA035430ms5954-327 day HS
SA035431ms5954-337 day HS
SA035432ms5954-107 day HS
SA035433ms5954-97 day HS
SA035434ms5954-317 day HS
SA035435ms5954-25Control
SA035436ms5954-26Control
SA035437ms5954-24Control
SA035438ms5954-19Control
SA035439ms5954-6Control
SA035440ms5954-7Control
SA035441ms5954-5Control
SA035442ms5954-4Control
SA035443ms5954-2Control
SA035444ms5954-3Control
SA035445ms5954-8Control
SA035446ms5954-17Control
SA035447ms5954-21Control
SA035448ms5954-22Control
SA035449ms5954-20Control
SA035450ms5954-1Control
SA035451ms5954-18Control
SA035452ms5954-23Control
Showing results 1 to 36 of 36
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