Summary of Study ST000911
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000631. The data can be accessed directly via it's Project DOI: 10.21228/M83T1G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST000911 |
Study Title | Insights into the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) through metabolomic profiling of cerebrospinal fluid (part II) |
Study Summary | Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling illness characterized by six months or more of unexplained profound fatigue with post-exertional malaise, sleep abnormalities, cognitive dysfunction and autonomic disturbances. Focusing on the pathogenesis of central nervous system abnormalities in ME/CFS, we pursued metabolomics analysis of cerebrospinal fluid (CSF) in 32 ME/CFS cases, 40 subjects with multiple sclerosis (MS), another fatiguing illness, and 19 healthy subjects with no neurological disease (ND). MS/ND subjects were frequency matched for age and sex to ME/CFS subjects. Three untargeted metabolomic assays for primary metabolites, biogenic amines and complex lipids were performed with gas chromatography time-of-flight (GC-TOF) and liquid chromatography–tandem mass spectrometry (LC-MS/MS) yielding profiles for 525 known metabolites. Mannose was a cardinal biomarker in ME/CFS subjects with reduced levels in ME/CFS compared to both MS and ND subjects. Levels of acetylcarnitine were reduced in ME/CFS vs. MS subjects. The predictive power of metabolomic analysis for diagnosis of ME/CFS vs. ND was higher (cross-validated AUC 0.875; 95% CI: 0.726~0.949) than with cytokine analysis alone (cross-validated AUC 0.865; 95% CI: 0.673~0.952) and improved with integration of both metabolomics and cytokine analyses (cross-validated AUC 0.916; 95% CI: 0.791~0.969). Our findings confirm the biological basis of ME/CFS, and may enable new methods for diagnosis and insight into cognitive and autonomic disturbances in this syndrome. |
Institute | University of California, Davis |
Department | Genome and Biomedical Sciences Facility |
Laboratory | WCMC Metabolomics Core |
Last Name | Fiehn |
First Name | Oliver |
Address | 1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616 |
ofiehn@ucdavis.edu | |
Phone | (530) 754-8258 |
Submit Date | 2017-12-11 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | LC-MS |
Release Date | 2018-08-27 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
mb_sample_id | local_sample_id | Diagnosis | Sex |
---|---|---|---|
SA053497 | Lipkin019_posCSH_DPCSF3671_034.d | MECFS | FEMALE |
SA053498 | Lipkin048_posCSH_DPCSF7598_086.d | MECFS | FEMALE |
SA053499 | Lipkin069_posCSH_DPCSF3712_009.d | MECFS | FEMALE |
SA053500 | Lipkin081_posCSH_DPCSF7638_068.d | MECFS | FEMALE |
SA053501 | Lipkin120_posCSH_DPCSF3152_084.d | MECFS | FEMALE |
SA053502 | Lipkin028_posCSH_DPCSF8065_085.d | MECFS | FEMALE |
SA053503 | Lipkin100_posCSH_DPCSF6448_016_2.d | MECFS | FEMALE |
SA053504 | Lipkin016_posCSH_DPCSF3752_069.d | MECFS | FEMALE |
SA053505 | Lipkin097_posCSH_DPCSF4353_065.d | MECFS | FEMALE |
SA053506 | Lipkin004_posCSH_DPCSF6529_083.d | MECFS | FEMALE |
SA053507 | Lipkin044_posCSH_DPCSF6143_067.d | MECFS | FEMALE |
SA053508 | Lipkin078_posCSH_DPCSF5981_073.d | MECFS | FEMALE |
SA053509 | Lipkin076_posCSH_DPCSF5502_070_2.d | MECFS | FEMALE |
SA053510 | Lipkin093_posCSH_DPCSF7263_094.d | MECFS | FEMALE |
SA053511 | Lipkin064_posCSH_DPCSF5421_088.d | MECFS | FEMALE |
SA053512 | Lipkin003_posCSH_DPCSF2216_007.d | MECFS | FEMALE |
SA053513 | Lipkin105_posCSH_DPCSF7944_046.d | MECFS | FEMALE |
SA053514 | Lipkin109_posCSH_DPCSF1870_082.d | MECFS | FEMALE |
SA053515 | Lipkin010_posCSH_DPCSF9145_018.d | MECFS | FEMALE |
SA053516 | Lipkin096_posCSH_DPCSF9226_039.d | MECFS | FEMALE |
SA053517 | Lipkin080_posCSH_DPCSF8371_014.d | MECFS | FEMALE |
SA053518 | Lipkin074_posCSH_DPCSF1495_036.d | MECFS | MALE |
SA053519 | Lipkin041_posCSH_DPCSF6765_032.d | MECFS | MALE |
SA053520 | Lipkin077_posCSH_DPCSF7476_001.d | MECFS | MALE |
SA053521 | Lipkin071_posCSH_DPCSF1576_044.d | MECFS | MALE |
SA053522 | Lipkin107_posCSH_DPCSF9012_005_3.d | MECFS | MALE |
SA053523 | Lipkin072_posCSH_DPCSF7863_071.d | MECFS | MALE |
SA053524 | Lipkin001_posCSH_DPCSF0426_003.d | MECFS | MALE |
SA053525 | Lipkin066_posCSH_DPCSF2603_048.d | MECFS | MALE |
SA053526 | Lipkin103_posCSH_DPCSF9826_2_BU.d | MECFS | MALE |
SA053527 | Lipkin110_posCSH_DPCSF2938_066.d | MECFS | MALE |
SA053528 | Lipkin037_posCSH_DPCSF3285_072.d | MECFS | MALE |
SA053529 | Lipkin011_posCSH_DPCSF6890_090.d | MS | FEMALE |
SA053530 | Lipkin101_posCSH_DPCSF9292_037.d | MS | FEMALE |
SA053531 | Lipkin075_posCSH_DPCSF9627_092.d | MS | FEMALE |
SA053532 | Lipkin106_posCSH_DPCSF6902_103.d | MS | FEMALE |
SA053533 | Lipkin023_posCSH_DPCSF9506_013.d | MS | FEMALE |
SA053534 | Lipkin099_posCSH_DPCSF6688_062.d | MS | FEMALE |
SA053535 | Lipkin068_posCSH_DPCSF8824_081.d | MS | FEMALE |
SA053536 | Lipkin030_posCSH_DPCSF7877_079.d | MS | FEMALE |
SA053537 | Lipkin053_posCSH_DPCSF7970_102.d | MS | FEMALE |
SA053538 | Lipkin117_posCSH_DPCSF8397_025.d | MS | FEMALE |
SA053539 | Lipkin032_posCSH_DPCSF8478_008.d | MS | FEMALE |
SA053540 | Lipkin091_posCSH_DPCSF8692_015_2.d | MS | FEMALE |
SA053541 | Lipkin090_posCSH_DPCSF7410_043.d | MS | FEMALE |
SA053542 | Lipkin094_posCSH_DPCSF8183_080.d | MS | FEMALE |
SA053543 | Lipkin029_posCSH_DPCSF7318_087.d | MS | FEMALE |
SA053544 | Lipkin057_posCSH_DPCSF6088_055.d | MS | FEMALE |
SA053545 | Lipkin046_posCSH_DPCSF1896_029.d | MS | FEMALE |
SA053546 | Lipkin087_posCSH_DPCSF3686_093.d | MS | FEMALE |
SA053547 | Lipkin119_posCSH_DPCSF4165_101.d | MS | FEMALE |
SA053548 | Lipkin007_posCSH_DPCSF4592_121.d | MS | FEMALE |
SA053549 | Lipkin014_posCSH_DPCSF1815_122.d | MS | FEMALE |
SA053550 | Lipkin027_posCSH_DPCSF1041_058.d | MS | FEMALE |
SA053551 | Lipkin089_posCSH_DPCSF0614_035_2.d | MS | FEMALE |
SA053552 | Lipkin042_posCSH_DPCSF0747_027.d | MS | FEMALE |
SA053553 | Lipkin104_posCSH_DPCSF0868_089_3.d | MS | FEMALE |
SA053554 | Lipkin049_posCSH_DPCSF4633_104.d | MS | FEMALE |
SA053555 | Lipkin063_posCSH_DPCSF3137_060.d | MS | FEMALE |
SA053556 | Lipkin052_posCSH_DPCSF5274_054.d | MS | FEMALE |
SA053557 | Lipkin118_posCSH_DPCSF1174_023.d | MS | MALE |
SA053558 | Lipkin065_posCSH_DPCSF8732_075.d | MS | MALE |
SA053559 | Lipkin033_posCSH_DPCSF5395_077.d | MS | MALE |
SA053560 | Lipkin035_posCSH_DPCSF5447_011_2.d | MS | MALE |
SA053561 | Lipkin031_posCSH_DPCSF4927_074.d | MS | MALE |
SA053562 | Lipkin067_posCSH_DPCSF6728_056.d | MS | MALE |
SA053563 | Lipkin102_posCSH_DPCSF0909_078.d | MS | MALE |
SA053564 | Lipkin018_posCSH_DPCSF9719_033.d | MS | MALE |
SA053565 | Lipkin020_posCSH_DPCSF2029_041.d | MS | MALE |
SA053566 | Lipkin086_posCSH_DPCSF7329_006.d | MS | MALE |
SA053567 | Lipkin050_posCSH_DPCSF7664_076.d | MS | MALE |
SA053568 | Lipkin045_posCSH_DPCSF7023_091.d | MS | MALE |
SA053569 | Lipkin036_posCSH_DPCSF6128_115.d | ND | FEMALE |
SA053570 | Lipkin024_posCSH_DPCSF0106_108.d | ND | FEMALE |
SA053571 | Lipkin034_posCSH_DPCSF0828_031.d | ND | FEMALE |
SA053572 | Lipkin098_posCSH_DPCSF7115_106.d | ND | FEMALE |
SA053573 | Lipkin005_posCSH_DPCSF7756_002.d | ND | FEMALE |
SA053574 | Lipkin116_posCSH_DPCSF6769_051.d | ND | FEMALE |
SA053575 | Lipkin113_posCSH_DPCSF6555_107.d | ND | FEMALE |
SA053576 | Lipkin056_posCSH_DPCSF0146_105.d | ND | FEMALE |
SA053577 | Lipkin108_posCSH_DPCSF2710_064.d | ND | FEMALE |
SA053578 | Lipkin039_posCSH_DPCSF3310_047.d | ND | FEMALE |
SA053579 | Lipkin009_posCSH_DPCSF9332_017.d | ND | FEMALE |
SA053580 | Lipkin114_posCSH_DPCSF7797_045.d | ND | FEMALE |
SA053581 | Lipkin084_posCSH_DPCSF1281_053.d | ND | FEMALE |
SA053582 | Lipkin055_posCSH_DPCSF1215_019.d | ND | MALE |
SA053583 | Lipkin059_posCSH_DPCSF2924_118.d | ND | MALE |
SA053584 | Lipkin038_posCSH_DPCSF2750_120.d | ND | MALE |
SA053585 | Lipkin092_posCSH_DPCSF2110_119.d | ND | MALE |
SA053586 | Lipkin043_posCSH_DPCSF8865_117.d | ND | MALE |
SA053587 | Lipkin051_posCSH_DPCSF3605_116.d | ND | MALE |
Showing results 1 to 91 of 91 |