Summary of Study ST000977

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000667. The data can be accessed directly via it's Project DOI: 10.21228/M8FX07 This work is supported by NIH grant, U2C- DK119886.

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Study IDST000977
Study TitleIdentification of unique metabolite networks between Latino and Caucasian patients with nonalcoholic fatty liver disease (NAFLD)
Study TypePopulations comparison
Study SummaryNonalcoholic fatty liver disease (NAFLD) is a spectrum of liver pathology ranging from simple steatosis to nonalcoholic steatohepatitis (NASH); the latter is characterized by inflammation and fibrosis. Risk factors for NALFD include obesity, diabetes, hyperlipidemia, and hypertension—all of which are features of metabolic syndrome. NAFLD is a very heterogeneous disease, as it presents in different patterns in males and females and in patients from different ethnicities, with unclear predictors for development and severity of disease. Previous studies have shown that NAFLD is 1.4 times more frequent in Hispanics than in Caucasians. One of the major challenges in NAFLD is the lack of accurate, noninvasive biomarkers for the detection of the most aggressive presentation, NASH. The gold standard for the diagnosis is liver biopsy, which is an invasive procedure associated with possible complications. Noninvasive diagnosis of NASH is a major unmet medical need and there are no ethnicity-specific biomarkers that can diagnose this condition and predict its progression. Therefore, the main gap in knowledge that this proposal and line of research will address is the characterizing the different plasma and liver metabolomics profile of patients with fatty liver from two ethnicities (Latinos vs. Caucasians) and of both sexes. The overall hypothesis of the present study is that the higher incidence of nonalcoholic fatty liver (NAFL) in Latino patients is reflected in a different plasma and liver metabolomics profile compared to Caucasian patients with further sex-related differences. Characterization of metabolite networks can aid in identifying the mechanistic underpinnings of sex and ethnic driven differences in NAFL which could help diagnose and establish a prognosis of this condition, especially in the critical transition from NAFL to the more aggressive nonalcoholic steatohepatitis (NASH).To address this hypothesis, plasma metabolomics profile of samples from male and female Latino and Caucasian bariatric surgery patients with NAFL and from healthy subjects will be compared. Metabolomics findings will be related with liver pathology and liver transcriptome profiles from intraoperatively obtained liver biopsies using correlation, network, and pathway analysis.
Institute
University of California, Davis
DepartmentGenome and Biomedical Sciences Facility
LaboratoryWCMC Metabolomics Core
Last NameFiehn
First NameOliver
Address1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616
Emailofiehn@ucdavis.edu
Phone(530) 754-8258
Submit Date2018-05-24
Num Groups8
Total Subjects40
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2018-07-17
Release Version1
Oliver Fiehn Oliver Fiehn
https://dx.doi.org/10.21228/M8FX07
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Ethnicity Gender Group
SA059409RB14 E05Caucasian Female Healthy Control
SA059410RB14 C06Caucasian Female Healthy Control
SA059411RB14 E07Caucasian Female Healthy Control
SA059412RB14 G05Caucasian Female Healthy Control
SA059413RB14 D08Caucasian Female NAFLD
SA059414RB14 D07Caucasian Female NAFLD
SA059415RB14 G06Caucasian Female NAFLD
SA059416RB14 B08Caucasian Female NAFLD
SA059417RB14 A04Caucasian Male Healthy Control
SA059418RB14 G03Caucasian Male Healthy Control
SA059419RB14 E04Caucasian Male Healthy Control
SA059420RB14 C05Caucasian Male Healthy Control
SA059421RB14 F03Caucasian Male NAFLD
SA059422RB14 A07Caucasian Male NAFLD
SA059423RB14 D05Caucasian Male NAFLD
SA059424RB14 F08Caucasian Male NAFLD
SA059425RB14 C08Hispanic Female Healthy Control
SA059426RB14 A06Hispanic Female Healthy Control
SA059427RB14 A05Hispanic Female Healthy Control
SA059428RB14 B07Hispanic Female Healthy Control
SA059429RB14 G08Hispanic Female Healthy Control
SA059430RB14 A09Hispanic Female Healthy Control
SA059431RB14 F05Hispanic Female NAFLD
SA059432RB14 B04Hispanic Female NAFLD
SA059433RB14 D06Hispanic Female NAFLD
SA059434RB14 H05Hispanic Female NAFLD
SA059435RB14 H08Hispanic Female NAFLD
SA059436RB14 H07Hispanic Female NAFLD
SA059437RB14 H03Hispanic Female NAFLD
SA059438RB14 H06Hispanic Male Healthy Control
SA059439RB14 E08Hispanic Male Healthy Control
SA059440RB14 C04Hispanic Male Healthy Control
SA059441RB14 C07Hispanic Male Healthy Control
SA059442RB14 E06Hispanic Male Healthy Control
SA059443RB14 F06Hispanic Male Healthy Control
SA059444RB14 A08Hispanic Male Healthy Control
SA059445RB14 G04Hispanic Male Healthy Control
SA059446RB14 F04Hispanic Male NAFLD
SA059447RB14 D04Hispanic Male NAFLD
SA059448RB14 B05Hispanic Male NAFLD
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