Summary of Study ST001036
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000693. The data can be accessed directly via it's Project DOI: 10.21228/M83H4H This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001036 |
| Study Title | TCA Concentrations in Neuromyelitis Optica Patients (part - II) |
| Study Summary | Patients with an inflammatory disease of the central nervous system known as neuromyelitis optica (NMO) experience increased levels of depression. These patients have an antibody that recognizes a type of cell in the brain called astrocytes – binding of this antibody to astrocytes triggers a stress response in the cell that results in the development of brain lesions that cause disability and cognitive disturbances. We recently observed a change in the level of glutamate in a part of the brain involved in depression in patients with NMO. Glutamate is a chemical that is used in the brain for communication between neurons – reduced levels of glutamate are thought to trigger depression by reducing neuronal activity in specific circuits. Based on this observation and the known role of astrocytes in maintaining glutamate levels in the brain, we hypothesize that the NMO antibody disturbs metabolic activity in astrocytes and thereby reduces glutamate and triggers depression. We intend to measure TCA concentration in NMO astrocytes. It is our hope that we will not only learn something about the mechanisms of astrocyte dysregulation in neuromyelitis optica, but that we will learn something about the mechanisms of depression in general that may lead to new therapies for this disease. |
| Institute | Mayo Clinic |
| Last Name | Howe |
| First Name | Charles |
| Address | 200 First St. SW, Rochester, Minnesota, 55905, USA |
| howe@mayo.edu | |
| Phone | 507-284-9288 |
| Submit Date | 2018-08-13 |
| Analysis Type Detail | GC-MS |
| Release Date | 2020-08-20 |
| Release Version | 1 |
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Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | Time Point | Matrix | Condition |
|---|---|---|---|---|
| SA069331 | ms6982-56 | 0h | Fresh Media | BGP 50uMGt Gn |
| SA069332 | ms6923-21 | 0h | Fresh Media | BGP50uMGt Gn |
| SA069333 | ms6923-19 | 0h | Fresh Media | BGPGt 0.5 mM Gn |
| SA069334 | ms6982-54 | 0h | Fresh Media | BGPGt 0.5mM Gn |
| SA069335 | ms6923-20 | 0h | Fresh Media | BGPGt 5mM Gn |
| SA069336 | ms6982-55 | 0h | Fresh Media | BGPGt 5mM Gn |
| SA069337 | ms6982-57 | 0h | Fresh Media | E Med |
| SA069338 | ms6923-22 | 0h | Fresh Media | E Med |
| SA069339 | ms6982-53 | 1h nonCO2 | Spent Sup | BGP50uMGt Gn |
| SA069340 | ms6923-18 | 1h nonCO2 | Spent Sup | BGP50uMGt Gn |
| SA069341 | ms6982-52 | 1h nonCO2 | Spent Sup | BGP50uMGt Gn |
| SA069342 | ms6982-51 | 1h nonCO2 | Spent Sup | BGP50uMGt Gn |
| SA069343 | ms6923-16 | 1h nonCO2 | Spent Sup | BGP50uMGt Gn |
| SA069344 | ms6923-17 | 1h nonCO2 | Spent Sup | BGP50uMGt Gn |
| SA069345 | ms6923-10 | 1h nonCO2 | Spent Sup | BGPGt 0.5 mM Gn |
| SA069346 | ms6923-12 | 1h nonCO2 | Spent Sup | BGPGt 0.5 mM Gn |
| SA069347 | ms6923-11 | 1h nonCO2 | Spent Sup | BGPGt 0.5 mM Gn |
| SA069348 | ms6982-46 | 1h nonCO2 | Spent Sup | BGPGt 0.5mM Gn |
| SA069349 | ms6982-45 | 1h nonCO2 | Spent Sup | BGPGt 0.5mM Gn |
| SA069350 | ms6982-47 | 1h nonCO2 | Spent Sup | BGPGt 0.5mM Gn |
| SA069351 | ms6982-50 | 1h nonCO2 | Spent Sup | BGPGt 5mM Gn |
| SA069352 | ms6982-48 | 1h nonCO2 | Spent Sup | BGPGt 5mM Gn |
| SA069353 | ms6923-13 | 1h nonCO2 | Spent Sup | BGPGt 5mM Gn |
| SA069354 | ms6982-49 | 1h nonCO2 | Spent Sup | BGPGt 5mM Gn |
| SA069355 | ms6923-14 | 1h nonCO2 | Spent Sup | BGPGt 5mM Gn |
| SA069356 | ms6923-15 | 1h nonCO2 | Spent Sup | BGPGt 5mM Gn |
| SA069366 | ms6982-43 | 23h +1h nonCO2 | pellet | BGP50uMGt Gn |
| SA069367 | ms6982-42 | 23h +1h nonCO2 | pellet | BGP50uMGt Gn |
| SA069368 | ms6982-44 | 23h +1h nonCO2 | pellet | BGP50uMGt Gn |
| SA069357 | ms6923-7 | 23h + 1h nonCO2 | Pellet | BGP50uMGt Gn |
| SA069358 | ms6923-8 | 23h + 1h nonCO2 | Pellet | BGP50uMGt Gn |
| SA069359 | ms6923-9 | 23h + 1h nonCO2 | Pellet | BGP50uMGt Gn |
| SA069369 | ms6982-36 | 23h +1h nonCO2 | pellet | BGPGt 0.5mM Gn |
| SA069370 | ms6982-38 | 23h +1h nonCO2 | pellet | BGPGt 0.5mM Gn |
| SA069371 | ms6982-37 | 23h +1h nonCO2 | pellet | BGPGt 0.5mM Gn |
| SA069360 | ms6923-3 | 23h + 1h nonCO2 | Pellet | BGPGt 0.5 mM Gn |
| SA069361 | ms6923-1 | 23h + 1h nonCO2 | Pellet | BGPGt 0.5 mM Gn |
| SA069362 | ms6923-2 | 23h + 1h nonCO2 | Pellet | BGPGt 0.5 mM Gn |
| SA069372 | ms6982-41 | 23h +1h nonCO2 | pellet | BGPGt 5mM Gn |
| SA069373 | ms6982-39 | 23h +1h nonCO2 | pellet | BGPGt 5mM Gn |
| SA069374 | ms6982-40 | 23h +1h nonCO2 | pellet | BGPGt 5mM Gn |
| SA069363 | ms6923-4 | 23h + 1h nonCO2 | Pellet | BGPGt 5mM Gn |
| SA069364 | ms6923-5 | 23h + 1h nonCO2 | Pellet | BGPGt 5mM Gn |
| SA069365 | ms6923-6 | 23h + 1h nonCO2 | Pellet | BGPGt 5mM Gn |
| SA069375 | ms6982-60 | 23h | Spent Sup | E Med |
| SA069376 | ms6982-58 | 23h | Spent Sup | E Med |
| SA069377 | ms6982-59 | 23h | Spent Sup | E Med |
| SA069378 | ms6923-26 | 23h | Spent Sup | E Med |
| SA069379 | ms6923-23 | 23h | Spent Sup | E Med |
| SA069380 | ms6923-24 | 23h | Spent Sup | E Med |
| SA069381 | ms6923-25 | 23h | Spent Sup | E Med |
| Showing results 1 to 51 of 51 |
