Summary of Study ST001069
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000716. The data can be accessed directly via it's Project DOI: 10.21228/M8496H This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001069 |
| Study Title | Evaluation of Seryl-leucine core 1 O-glycosylated peptide (SLC1G) in TB patient urine |
| Study Summary | Previous work detected an uncharacterized urine metabolite with a molecular mass of 874.3547 Da that showed promise as a biomarker for successful TB treatment. Using mass spectrometry combined with enzymatic digestions, the metabolite was structurally characterized as a seryl-leucine core 1 O-glycosylated peptide (SLC1G) of human origin. Examination of SLC1G in urine revealed a significant abundance increase in individuals with active TB versus their household contacts and healthy controls. Moreover, differential decreases in SLC1G levels were observed by week-one in TB patients during successful treatment versus those that failed treatment. The SLC1G levels also associated with clinical parameters used to measure bacterial burden (GeneXpert) and inflammation (PET-CT). These results demonstrate the importance of metabolite identification and provide strong evidence for applying SLC1G as a biomarker of TB treatment response. |
| Institute | Colorado State University |
| Last Name | Fitzgerald |
| First Name | Bryna |
| Address | 3185 Rampart Rd |
| blfitz@colostate.edu | |
| Phone | 9704918905 |
| Submit Date | 2018-10-07 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | LC-MS |
| Release Date | 2018-12-11 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | Sample Type |
|---|---|---|
| SA072112 | 49_417599 | Cure |
| SA072113 | 49_452751 | Cure |
| SA072114 | 52_417241 | Cure |
| SA072115 | 49_417420 | Cure |
| SA072116 | 49_417104 | Cure |
| SA072117 | 54_417397 | Cure |
| SA072118 | 53_452557 | Cure |
| SA072119 | 52_417306 | Cure |
| SA072120 | 49_417197 | Cure |
| SA072121 | 52_417612 | Cure |
| SA072122 | 70_452598 | Cure |
| SA072123 | 70_452879 | Cure |
| SA072124 | 54_453981 | Cure |
| SA072125 | 53_417432 | Cure |
| SA072126 | 53_417276 | Cure |
| SA072127 | 53_452177 | Cure |
| SA072128 | 52_453273 | Cure |
| SA072129 | 53_417231 | Cure |
| SA072130 | 52_417327 | Cure |
| SA072131 | 42_417730 | Cure |
| SA072132 | 4_413165 | Cure |
| SA072133 | 4_413529 | Cure |
| SA072134 | 4_415983 | Cure |
| SA072135 | 4_412676 | Cure |
| SA072136 | 4_412467 | Cure |
| SA072137 | 54_452300 | Cure |
| SA072138 | 54_417543 | Cure |
| SA072139 | 54_417526 | Cure |
| SA072140 | 41_416680 | Cure |
| SA072141 | 41_416839 | Cure |
| SA072142 | 42_417082 | Cure |
| SA072143 | 42_417298 | Cure |
| SA072144 | 70_454358 | Cure |
| SA072145 | 70_452497 | Cure |
| SA072146 | 42_416647 | Cure |
| SA072147 | 41_417796 | Cure |
| SA072148 | 41_417812 | Cure |
| SA072149 | 41_452528 | Cure |
| SA072150 | 42_452621 | Cure |
| SA072151 | 70_453399 | Cure |
| SA072152 | 133_6017982 | Cure |
| SA072153 | 133_6015609 | Cure |
| SA072154 | 133_6015265 | Cure |
| SA072155 | 84_450359 | Cure |
| SA072156 | 99_450530 | Cure |
| SA072157 | 72_452579 | Cure |
| SA072158 | 77_454840 | Cure |
| SA072159 | 99_455509 | Cure |
| SA072160 | 133_6015125 | Cure |
| SA072161 | 84_454074 | Cure |
| SA072162 | 9_413423 | Cure |
| SA072163 | 9_414448 | Cure |
| SA072164 | 9_416315 | Cure |
| SA072165 | 9_413209 | Cure |
| SA072166 | 9_413017 | Cure |
| SA072167 | 84_454302 | Cure |
| SA072168 | 84_454456 | Cure |
| SA072169 | 84_454731 | Cure |
| SA072170 | 99_455537 | Cure |
| SA072171 | 99_6016048 | Cure |
| SA072172 | 72_452697 | Cure |
| SA072173 | 72_452708 | Cure |
| SA072174 | 72_453409 | Cure |
| SA072175 | 144_6016655 | Cure |
| SA072176 | 144_6016764 | Cure |
| SA072177 | 144_6019586 | Cure |
| SA072178 | 144_6017656 | Cure |
| SA072179 | 144_6017147 | Cure |
| SA072180 | 72_454467 | Cure |
| SA072181 | 76_452740 | Cure |
| SA072182 | 77_453331 | Cure |
| SA072183 | 77_453575 | Cure |
| SA072184 | 77_453869 | Cure |
| SA072185 | 77_453178 | Cure |
| SA072186 | 76_454831 | Cure |
| SA072187 | 76_453251 | Cure |
| SA072188 | 76_453628 | Cure |
| SA072189 | 76_453992 | Cure |
| SA072190 | 99_450109 | Cure |
| SA072191 | 43_416824 | Fail |
| SA072192 | 43_452641 | Fail |
| SA072193 | 43_417332 | Fail |
| SA072194 | 43_416760 | Fail |
| SA072195 | 43_416684 | Fail |
| SA072196 | 19_415454 | Fail |
| SA072197 | 169_6020182 | Fail |
| SA072198 | 169_6018329 | Fail |
| SA072199 | 169_6017991 | Fail |
| SA072200 | 169_6017639 | Fail |
| SA072201 | 19_413660 | Fail |
| SA072202 | 19_413693 | Fail |
| SA072203 | 21_413701 | Fail |
| SA072204 | 19_416777 | Fail |
| SA072205 | 19_414721 | Fail |
| SA072206 | 169_6017465 | Fail |
| SA072207 | 168_6020172 | Fail |
| SA072208 | 163_6018193 | Fail |
| SA072209 | 163_6017645 | Fail |
| SA072210 | 163_6017429 | Fail |
| SA072211 | 163_6017331 | Fail |
