Summary of Study ST001104

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000716. The data can be accessed directly via it's Project DOI: 10.21228/M8496H This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST001104
Study TitleSeryl-leucine core 1 O-glycosylated peptide (SLC1G) identification
Study SummaryAn untargeted metabolomics approach was utilized to determine urinary metabolites that could serve as small molecule biomarkers for treatment response to standard tuberculosis treatment. However, the majority of metabolites that most accurately distinguished patient samples at time of diagnosis from those at one month after the start of therapy lacked structural identification. The detection of unknown metabolite structures is a well-known limitation of untargeted metabolomics, and underscores a need for continued elucidation of novel metabolite structures. In this study, we sought to define the structure of a urine metabolite with an experimentally determined mass of 202.1326 Da, classified as molecular feature (MF) 874.3547. Using mass spectrometry combined with enzymatic digestions, the metabolite was structurally characterized as a seryl-leucine core 1 O-glycosylated peptide (SLC1G) of human origin.
Institute
Colorado State University
Last NameFitzgerald
First NameBryna
Address3185 Rampart Rd
Emailblfitz@colostate.edu
Phone9704918905
Submit Date2018-09-26
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2019-01-22
Release Version1
Bryna Fitzgerald Bryna Fitzgerald
https://dx.doi.org/10.21228/M8496H
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sample Type
SA075182SLC1G_only.dEnriched SLC1G
SA075184SLC1G+a2-368.dEnriched SLC1G after treatment with a2-3,6,8 neuraminidase
SA075185SLC1G+both.dEnriched SLC1G after treatment with a2-3,6,8 neuraminidase and O-glycosidase
SA075186SLC1G+both-r002.dEnriched SLC1G after treatment with a2-3,6,8 neuraminidase and O-glycosidase for comparison with seryl-leucine standard
SA075187SLC1G+both_10.dEnriched SLC1G after treatment with a2-3,6,8 neuraminidase and O-glycosidase for comparison with seryl-leucine standard
SA075183SLC1G+a2-3.dEnriched SLC1G after treatment with a2-3 neuraminidase
SA0751887728_CE20.dPatient urine
SA075189SL_10.dSeryl-leucine Standard
SA075190SL-r002.dSeryl-leucine Standard
Showing results 1 to 9 of 9
  logo