Summary of Study ST001171

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000783. The data can be accessed directly via it's Project DOI: 10.21228/M8G970 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001171
Study TitleMetabolomics of World Trade Center Exposed New York City Firefighters
Study TypeC18 Reversed-Phase Broad Spectrum Metabolomics
Study SummaryParticulate matter (PM) exposure and metabolic syndrome (MetSyn) coexist in both industrialized and developing nations. PM and MetSyn are strong risk factors for chronic obstructive pulmonary disease (COPD) and asthma. After the World Trade Center collapse in 9/11/2001, PM-exposed individuals from the Fire Department of New York City (FDNY) developed a progressively lung disease. This nested case-cohort study is composed of never smoking, WTC exposed firefighters with normal pre-9/11 lung function presenting for subspecialty pulmonary evaluation (SPE) before March 2008. Representative cohort controls with serum drawn within six months of 9/11 (n=100). FEV1 at subspecialty exam defined cases: susceptible World Trade Center Lung Injury (WTC-LI) cases (n=50) had FEV1< lower limit of normal (LLN) and resistant WTC-LI cases with FEV1 ≥107% predicted (n=50). This study will determine the metabolomics profile that differentiates firefighters with WTC-LI, firefighters resistant to WTC-LI, and similarly exposed cohort controls.
Institute
New York University
DepartmentSchool of Medicine
LaboratoryLaboratory at NYU/Bellevue
Last NameNolan
First NameAnna
AddressAcademic office 462 1st Avenue, New Bellevue 16, S 16(Office)/ N 20 (Lab) New York, NY 10016
Emailanna.nolan@nyulangone.org
Phone212-263-7283
Submit Date2019-02-22
Num Groups3
Total Subjects224, 200 study samples, 24 pools
Num Males200
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2021-02-26
Release Version1
Anna Nolan Anna Nolan
https://dx.doi.org/10.21228/M8G970
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Age Group Group
SA080996S_11[20,30) yrs Control
SA080997S_60[20,30) yrs Resistant
SA080998S_91[20,30) yrs Resistant
SA080999S_94[20,30) yrs WTC-LI
SA081000S_195[30-40) yrs Control
SA081001S_183[30-40) yrs Control
SA081002S_182[30-40) yrs Control
SA081003S_178[30-40) yrs Control
SA081004S_103[30-40) yrs Control
SA081005S_19[30-40) yrs Control
SA081006S_106[30-40) yrs Control
SA081007S_20[30-40) yrs Control
SA081008S_52[30-40) yrs Control
SA081009S_33[30-40) yrs Control
SA081010S_32[30-40) yrs Control
SA081011S_51[30-40) yrs Control
SA081012S_38[30-40) yrs Control
SA081013S_40[30-40) yrs Control
SA081014S_10[30-40) yrs Control
SA081015S_48[30-40) yrs Control
SA081016S_101[30-40) yrs Control
SA081017S_29[30-40) yrs Control
SA081018S_21[30-40) yrs Control
SA081019S_199[30-40) yrs Control
SA081020S_58[30-40) yrs Control
SA081021S_22[30-40) yrs Control
SA081022S_24[30-40) yrs Control
SA081023S_53[30-40) yrs Control
SA081024S_54[30-40) yrs Control
SA081025S_197[30-40) yrs Control
SA081026S_70[30-40) yrs Control
SA081027S_87[30-40) yrs Control
SA081028S_88[30-40) yrs Control
SA081029S_139[30-40) yrs Control
SA081030S_86[30-40) yrs Control
SA081031S_114[30-40) yrs Control
SA081032S_108[30-40) yrs Control
SA081033S_113[30-40) yrs Control
SA081034S_90[30-40) yrs Control
SA081035S_134[30-40) yrs Control
SA081036S_124[30-40) yrs Control
SA081037S_96[30-40) yrs Control
SA081038S_93[30-40) yrs Control
SA081039S_128[30-40) yrs Control
SA081040S_132[30-40) yrs Control
SA081041S_130[30-40) yrs Control
SA081042S_8[30-40) yrs Control
SA081043S_83[30-40) yrs Control
SA081044S_167[30-40) yrs Control
SA081045S_165[30-40) yrs Control
SA081046S_73[30-40) yrs Control
SA081047S_97[30-40) yrs Resistant
SA081048S_56[30-40) yrs Resistant
SA081049S_78[30-40) yrs Resistant
SA081050S_9[30-40) yrs Resistant
SA081051S_57[30-40) yrs Resistant
SA081052S_3[30-40) yrs Resistant
SA081053S_166[30-40) yrs Resistant
SA081054S_13[30-40) yrs Resistant
SA081055S_17[30-40) yrs Resistant
SA081056S_191[30-40) yrs Resistant
SA081057S_174[30-40) yrs Resistant
SA081058S_28[30-40) yrs Resistant
SA081059S_105[30-40) yrs Resistant
SA081060S_89[30-40) yrs WTC-LI
SA081061S_136[30-40) yrs WTC-LI
SA081062S_69[30-40) yrs WTC-LI
SA081063S_67[30-40) yrs WTC-LI
SA081064S_65[30-40) yrs WTC-LI
SA081065S_179[30-40) yrs WTC-LI
SA081066S_116[30-40) yrs WTC-LI
SA081067S_194[30-40) yrs WTC-LI
SA081068S_107[30-40) yrs WTC-LI
SA081069S_102[30-40) yrs WTC-LI
SA081070S_77[30-40) yrs WTC-LI
SA081071S_159[30-40) yrs WTC-LI
SA081072S_55[30-40) yrs WTC-LI
SA081073S_154[30-40) yrs WTC-LI
SA081074S_164[30-40) yrs WTC-LI
SA081075S_184[30-40) yrs WTC-LI
SA081076S_2[30-40) yrs WTC-LI
SA081077S_171[30-40) yrs WTC-LI
SA081078S_44[40-50) yrs Control
SA081079S_45[40-50) yrs Control
SA081080S_79[40-50) yrs Control
SA081081S_95[40-50) yrs Control
SA081082S_61[40-50) yrs Control
SA081083S_92[40-50) yrs Control
SA081084S_74[40-50) yrs Control
SA081085S_80[40-50) yrs Control
SA081086S_192[40-50) yrs Control
SA081087S_121[40-50) yrs Control
SA081088S_122[40-50) yrs Control
SA081089S_172[40-50) yrs Control
SA081090S_119[40-50) yrs Control
SA081091S_175[40-50) yrs Control
SA081092S_18[40-50) yrs Control
SA081093S_177[40-50) yrs Control
SA081094S_140[40-50) yrs Control
SA081095S_137[40-50) yrs Control
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