Summary of Study ST001406

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000963. The data can be accessed directly via it's Project DOI: 10.21228/M86X2T This work is supported by NIH grant, U2C- DK119886.

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Study IDST001406
Study TitleEnvironmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach (part-II)
Study TypeSubcutaneous adipose tissue (AT); Visceral AT; Liver Tissue; Plasma
Study SummaryBackground: Advances in untargeted metabolomic technologies have great potential for insight into adverse metabolic effects underlying exposure to environmental chemicals. However, important challenges need to be addressed, including how biological response corresponds to the environmental chemical burden in different target tissues. Aim: We performed a pilot study using state-of-the-art ultra-high-resolution mass spectrometry (UHRMS) to characterize the burden of lipophilic persistent organic pollutants (POPs) in metabolic tissues and associated alterations in the plasma metabolome. Methods: We studied 11 adolescents with severe obesity at the time of bariatric surgery. We measured 18 POPs that can act as endocrine and metabolic disruptors (i.e. 2 dioxins, 11 organochlorine compounds [OCs] and 5 polybrominated diphenyl ethers [PBDEs]) in visceral and subcutaneous abdominal adipose tissue (vAT and sAT), and liver samples using gas chromatography with UHRMS. Biological pathways were evaluated by measuring the plasma metabolome using high-resolution metabolomics. Network and pathway enrichment analysis assessed correlations between the tissue-specific burden of three frequently detected POPs (i.e. p,p’-dichlorodiphenyldichloroethene [DDE], hexachlorobenzene [HCB] and PBDE-47) and plasma metabolic pathways. Results: Concentrations of 4 OCs and 3 PBDEs were quantifiable in at least one metabolic tissue for >80% of participants. All POPs had the highest median concentrations in adipose tissue, especially sAT, except for PBDE-154, which had comparable average concentrations across all tissues. Pathway analysis showed high correlations between tissue-specific POPs and metabolic alterations in pathways of amino acid metabolism, lipid and fatty acid metabolism, and carbohydrate metabolism. Conclusions: Most of the measured POPs appear to accumulate preferentially in adipose tissue compared to liver. Findings of plasma metabolic pathways potentially associated with tissue-specific POPs concentrations merit further investigation in larger populations.
Institute
Icahn School of Medicine at Mount Sinai
DepartmentEnvironmental Medicine and Public Health
LaboratoryHigh Resolution Exposomics Research Group
Last NameWalker
First NameDoug
AddressOne Gustave L. Levy Place, Box 1057, New York, NY 10029
Emaildouglas.walker@mssm.edu
Phone212-241-9891
Submit Date2020-06-19
Num Groups4
Total Subjects11
Num Males1
Num Females10
Study CommentsUpload #1: Visceral and subcutaneous abdominal adipose tissue, liver tissue. Plasma metabolomics are in upload #2
PublicationsValvi D, Walker DI, Inge T, Bartell SM, Jenkins T, Helmrath M, Ziegler TR, La Merrill MA, Eckel SP, Conti D, Liang Y, Jones DP, McConnell R, Chatzi L. (2020). Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach. Environment International. In Press.
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailGC-MS
Release Date2021-06-19
Release Version1
Doug Walker Doug Walker
https://dx.doi.org/10.21228/M86X2T
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Tissue Type
SA114151POTR_11_sATINTRA-ABDOMINAL ADIPOSE TISSUE
SA114152POTR_12_sATINTRA-ABDOMINAL ADIPOSE TISSUE
SA114153POTR_03_sATINTRA-ABDOMINAL ADIPOSE TISSUE
SA114154POTR_02_sATINTRA-ABDOMINAL ADIPOSE TISSUE
SA114155POTR_09_sATINTRA-ABDOMINAL ADIPOSE TISSUE
SA114156POTR_10_sATINTRA-ABDOMINAL ADIPOSE TISSUE
SA114157POTR_08_sATINTRA-ABDOMINAL ADIPOSE TISSUE
SA114158POTR_04_sATINTRA-ABDOMINAL ADIPOSE TISSUE
SA114159POTR_06_sATINTRA-ABDOMINAL ADIPOSE TISSUE
SA114160POTR_05_sATINTRA-ABDOMINAL ADIPOSE TISSUE
SA114161POTR_07_sATINTRA-ABDOMINAL ADIPOSE TISSUE
SA114162POTR_07_LiverLIVER
SA114163POTR_06_LiverLIVER
SA114164POTR_04_LiverLIVER
SA114165POTR_02_LiverLIVER
SA114166POTR_05_LiverLIVER
SA114167POTR_03_LiverLIVER
SA114168POTR_12_LiverLIVER
SA114169POTR_11_LiverLIVER
SA114170POTR_10_LiverLIVER
SA114171POTR_09_LiverLIVER
SA114172POTR_08_LiverLIVER
SA114173POTR_07_vATSUBCUTANEOUS ADIPOSE TISSUE
SA114174POTR_05_vATSUBCUTANEOUS ADIPOSE TISSUE
SA114175POTR_04_vATSUBCUTANEOUS ADIPOSE TISSUE
SA114176POTR_03_vATSUBCUTANEOUS ADIPOSE TISSUE
SA114177POTR_02_vATSUBCUTANEOUS ADIPOSE TISSUE
SA114178POTR_06_vATSUBCUTANEOUS ADIPOSE TISSUE
SA114179POTR_08_vATSUBCUTANEOUS ADIPOSE TISSUE
SA114180POTR_11_vATSUBCUTANEOUS ADIPOSE TISSUE
SA114181POTR_10_vATSUBCUTANEOUS ADIPOSE TISSUE
SA114182POTR_09_vATSUBCUTANEOUS ADIPOSE TISSUE
SA114183POTR_12_vATSUBCUTANEOUS ADIPOSE TISSUE
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