Summary of Study ST001407

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000963. The data can be accessed directly via it's Project DOI: 10.21228/M86X2T This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001407
Study TitleEnvironmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach
Study TypeSubcutaneous adipose tissue (AT); Visceral AT; Liver Tissue; Plasma
Study SummaryBackground: Advances in untargeted metabolomic technologies have great potential for insight into adverse metabolic effects underlying exposure to environmental chemicals. However, important challenges need to be addressed, including how biological response corresponds to the environmental chemical burden in different target tissues. Aim: We performed a pilot study using state-of-the-art ultra-high-resolution mass spectrometry (UHRMS) to characterize the burden of lipophilic persistent organic pollutants (POPs) in metabolic tissues and associated alterations in the plasma metabolome. Methods: We studied 11 adolescents with severe obesity at the time of bariatric surgery. We measured 18 POPs that can act as endocrine and metabolic disruptors (i.e. 2 dioxins, 11 organochlorine compounds [OCs] and 5 polybrominated diphenyl ethers [PBDEs]) in visceral and subcutaneous abdominal adipose tissue (vAT and sAT), and liver samples using gas chromatography with UHRMS. Biological pathways were evaluated by measuring the plasma metabolome using high-resolution metabolomics. Network and pathway enrichment analysis assessed correlations between the tissue-specific burden of three frequently detected POPs (i.e. p,p’-dichlorodiphenyldichloroethene [DDE], hexachlorobenzene [HCB] and PBDE-47) and plasma metabolic pathways. Results: Concentrations of 4 OCs and 3 PBDEs were quantifiable in at least one metabolic tissue for >80% of participants. All POPs had the highest median concentrations in adipose tissue, especially sAT, except for PBDE-154, which had comparable average concentrations across all tissues. Pathway analysis showed high correlations between tissue-specific POPs and metabolic alterations in pathways of amino acid metabolism, lipid and fatty acid metabolism, and carbohydrate metabolism. Conclusions: Most of the measured POPs appear to accumulate preferentially in adipose tissue compared to liver. Findings of plasma metabolic pathways potentially associated with tissue-specific POPs concentrations merit further investigation in larger populations.
Institute
Icahn School of Medicine at Mount Sinai
DepartmentEnvironmental Medicine and Public Health
LaboratoryHigh Resolution Exposomics Research Group
Last NameWalker
First NameDoug
AddressOne Gustave L. Levy Place, Box 1057, New York, NY 10029
Emaildouglas.walker@mssm.edu
Phone212-241-9891
Submit Date2020-06-22
Num Groups1
Total Subjects11
Num Males1
Num Females10
Study CommentsUpload #1: Visceral and subcutaneous abdominal adipose tissue, liver tissue. Plasma metabolomics are in upload #2
PublicationsValvi D, Walker DI, Inge T, Bartell SM, Jenkins T, Helmrath M, Ziegler TR, La Merrill MA, Eckel SP, Conti D, Liang Y, Jones DP, McConnell R, Chatzi L. (2020). Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach. Environment International. In Press.
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2021-06-19
Release Version1
Doug Walker Doug Walker
https://dx.doi.org/10.21228/M86X2T
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Description
SA114184chearplasma_1cCHEAR plasma pool
SA114185chearplasma_1dCHEAR plasma pool
SA114186chearplasma_1bCHEAR plasma pool
SA114187chearplasma_1aCHEAR plasma pool
SA114188NIST_1958_2NIST 1958
SA114189NIST_1958_1NIST 1958
SA114190POTR_02_PlasmaPOTR_02
SA114191POTR_03_PlasmaPOTR_03
SA114192POTR_04_PlasmaPOTR_04
SA114193POTR_05_PlasmaPOTR_05
SA114194POTR_06_PlasmaPOTR_06
SA114195POTR_07_PlasmaPOTR_07
SA114196POTR_08_PlasmaPOTR_08
SA114197POTR_09_PlasmaPOTR_09
SA114198POTR_10_PlasmaPOTR_10
SA114199POTR_11_PlasmaPOTR_11
SA114200POTR_12_PlasmaPOTR_12
SA114201q3June2014_1aQ-Standard plasma pool
SA114202q3June2014_1bQ-Standard plasma pool
SA114203q3June2014_1dQ-Standard plasma pool
SA114204q3June2014_1cQ-Standard plasma pool
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