Summary of Study ST001867

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001179. The data can be accessed directly via it's Project DOI: 10.21228/M89M5S This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001867
Study TitleSodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor (part I)
Study Typeuntargeted NMR analysis-cpmg
Study SummaryPrevious studies in our laboratory have suggested that the increase in stillbirth in pregnancies complicated by chronic maternal stress or hypercortisolemia is associated with cardiac dysfunction in late stages of labor and delivery. Transcriptomics analysis of the overly represented differentially expressed genes in the fetal heart of hypercortisolemic ewes indicated involvement of mitochondrial function. Sodium dichloroacetate (DCA) has been used to improve mitochondrial function in several disease states. We hypothesized that administration of DCA to laboring ewes would improve both cardiac mitochondrial activity and cardiac function in their fetuses. Four groups of ewes and their fetuses were studied: control, cortisol-infused (1 g/kg/d from 115 to term; CORT), DCA-treated (over 24h) or DCA+CORT-treated; oxytocin was delivered starting 48h before the DCA treatment. DCA significantly decreased cardiac lactate, alanine and glucose/glucose-6-phosphate and increased acylcarnitine/isobutyryl-carnitine. DCA increased mitochondrial activity, increasing oxidative phosphorylation (PCI, PCI+II)) per tissue weight or per unit of citrate synthase. DCA also decreased the duration of the QRS, attenuating the prolongation of the QRS observed in CORT fetuses. The effect to reduce QRS duration with DCA treatment correlated with increased glycerophosphocholine and serine and decreased phophocholine after DCA treatment. There were negative correlations of acylcarnitine/isobutyryl-carnitine to both HR and MAP. These results suggest that improvements in mitochondrial respiration with DCA produced changes in the cardiac lipid metabolism that favor improved conduction in the heart. DCA may therefore be an effective treatment of fetal cardiac metabolic disturbances in labor that can contribute to impairments of fetal cardiac conduction.
Institute
University of Georgia
DepartmentBiochemistry and Molecular Biology and Complex Carbohydrate Research Center, Department of Pharmacodynamics (University of Florida), Department of Physiology and Functional Genomics (University of Florida)
LaboratoryEdison Lab, Keller-Wood Lab, and Wood Lab
Last NameZhang
First NameSicong
Address315 Riverbend Road, Complex Carbohydrate Research Center
Emailsz91614@uga.edu
Phone7067151662
Submit Date2021-07-01
Num Groups4
Total Subjects29
PublicationsSodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor DOI:https://doi.org/10.1152/ajpregu.00185.2021
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2021-07-22
Release Version1
Sicong Zhang Sicong Zhang
https://dx.doi.org/10.21228/M89M5S
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Ovis aries (Factor headings shown in green)

mb_sample_id local_sample_id Cortisol treatment DCA treatment
SA1745081656_RControl Control
SA1745091532_RControl Control
SA1745101324_LControl Control
SA1745111427_SControl Control
SA1745121611_SControl Control
SA1745131532_LControl Control
SA1745141775_SControl Control
SA1745151775_RControl Control
SA1745161611_RControl Control
SA1745171254_RControl Control
SA1745181775B_RControl Control
SA1745191324_RControl Control
SA1745201254_SControl Control
SA1745211427_RControl Control
SA1745221656_LControl Control
SA1745231775B_LControl Control
SA1745241532_SControl Control
SA1745251611_LControl Control
SA1745261656_SControl Control
SA1745271427_LControl Control
SA1745281775_LControl Control
SA1745291324_SControl Control
SA1745301254_LControl Control
SA1745311775B_SControl Control
SA1745321269_SControl DCA-treated (over 24h)
SA1745331401_RControl DCA-treated (over 24h)
SA1745341401_SControl DCA-treated (over 24h)
SA1745351356_RControl DCA-treated (over 24h)
SA1745363019_RControl DCA-treated (over 24h)
SA1745371269_RControl DCA-treated (over 24h)
SA1745381682_LControl DCA-treated (over 24h)
SA1745393022_SControl DCA-treated (over 24h)
SA1745401277_SControl DCA-treated (over 24h)
SA1745411603_SControl DCA-treated (over 24h)
SA1745421356_SControl DCA-treated (over 24h)
SA1745431719_SControl DCA-treated (over 24h)
SA1745441277_RControl DCA-treated (over 24h)
SA1745453019_SControl DCA-treated (over 24h)
SA1745461603_RControl DCA-treated (over 24h)
SA1745471682_SControl DCA-treated (over 24h)
SA1745483022_RControl DCA-treated (over 24h)
SA1745493022_LControl DCA-treated (over 24h)
SA1745501603_LControl DCA-treated (over 24h)
SA1745511277_LControl DCA-treated (over 24h)
SA1745521356_LControl DCA-treated (over 24h)
SA1745531719_LControl DCA-treated (over 24h)
SA1745541401_LControl DCA-treated (over 24h)
SA1745551719_RControl DCA-treated (over 24h)
SA1745561269_LControl DCA-treated (over 24h)
SA1745573019_LControl DCA-treated (over 24h)
SA1745581682_RControl DCA-treated (over 24h)
SA1745591261_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745601329_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745611397_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745621727_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745631397_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745641448_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745651448_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745661727_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745671565_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745681428_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745691397_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745701261_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745711329_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745721428_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745731261_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745741329_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745751565_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745761428_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745771448_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745781727_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745791565_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1745801212_LCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745811445_SCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745821668_LCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745831642_SCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745841668_SCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745851642_RCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745861445_RCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745871668_RCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745881606_RCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745891642_LCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745901445_LCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745911212_SCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745921606_LCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745931212_RCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1745941606_SCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
Showing results 1 to 87 of 87
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