Summary of Study ST001868

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001179. The data can be accessed directly via it's Project DOI: 10.21228/M89M5S This work is supported by NIH grant, U2C- DK119886.

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This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001868
Study TitleSodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor (part II)
Study Typeuntargeted NMR analysis-noesy
Study SummaryPrevious studies in our laboratory have suggested that the increase in stillbirth in pregnancies complicated by chronic maternal stress or hypercortisolemia is associated with cardiac dysfunction in late stages of labor and delivery. Transcriptomics analysis of the overly represented differentially expressed genes in the fetal heart of hypercortisolemic ewes indicated involvement of mitochondrial function. Sodium dichloroacetate (DCA) has been used to improve mitochondrial function in several disease states. We hypothesized that administration of DCA to laboring ewes would improve both cardiac mitochondrial activity and cardiac function in their fetuses. Four groups of ewes and their fetuses were studied: control, cortisol-infused (1 g/kg/d from 115 to term; CORT), DCA-treated (over 24h) or DCA+CORT-treated; oxytocin was delivered starting 48h before the DCA treatment. DCA significantly decreased cardiac lactate, alanine and glucose/glucose-6-phosphate and increased acylcarnitine/isobutyryl-carnitine. DCA increased mitochondrial activity, increasing oxidative phosphorylation (PCI, PCI+II)) per tissue weight or per unit of citrate synthase. DCA also decreased the duration of the QRS, attenuating the prolongation of the QRS observed in CORT fetuses. The effect to reduce QRS duration with DCA treatment correlated with increased glycerophosphocholine and serine and decreased phophocholine after DCA treatment. There were negative correlations of acylcarnitine/isobutyryl-carnitine to both HR and MAP. These results suggest that improvements in mitochondrial respiration with DCA produced changes in the cardiac lipid metabolism that favor improved conduction in the heart. DCA may therefore be an effective treatment of fetal cardiac metabolic disturbances in labor that can contribute to impairments of fetal cardiac conduction.
Institute
University of Georgia
DepartmentBiochemistry and Molecular Biology and Complex Carbohydrate Research Center, Department of Pharmacodynamics (University of Florida), Department of Physiology and Functional Genomics (University of Florida)
LaboratoryEdison Lab, Keller-Wood Lab, and Wood Lab
Last NameZhang
First NameSicong
Address315 Riverbend Road, Complex Carbohydrate Research Center
Emailsz91614@uga.edu
Phone7067151662
Submit Date2021-07-01
Num Groups4
Total Subjects29
PublicationsSodium dichloroacetate stimulates cardiac mitochondrial metabolism and improves cardiac conduction in the ovine fetus during labor DOI:https://doi.org/10.1152/ajpregu.00185.2021
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2021-07-22
Release Version1
Sicong Zhang Sicong Zhang
https://dx.doi.org/10.21228/M89M5S
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Ovis aries (Factor headings shown in green)

mb_sample_id local_sample_id Cortisol treatment DCA treatment
SA1745951656_RControl Control
SA1745961532_RControl Control
SA1745971324_LControl Control
SA1745981427_SControl Control
SA1745991611_SControl Control
SA1746001532_LControl Control
SA1746011775_SControl Control
SA1746021775_RControl Control
SA1746031611_RControl Control
SA1746041254_RControl Control
SA1746051775B_RControl Control
SA1746061324_RControl Control
SA1746071254_SControl Control
SA1746081427_RControl Control
SA1746091656_LControl Control
SA1746101775B_LControl Control
SA1746111532_SControl Control
SA1746121611_LControl Control
SA1746131656_SControl Control
SA1746141427_LControl Control
SA1746151775_LControl Control
SA1746161324_SControl Control
SA1746171254_LControl Control
SA1746181775B_SControl Control
SA1746191269_SControl DCA-treated (over 24h)
SA1746201401_RControl DCA-treated (over 24h)
SA1746211401_SControl DCA-treated (over 24h)
SA1746221356_RControl DCA-treated (over 24h)
SA1746233019_RControl DCA-treated (over 24h)
SA1746241269_RControl DCA-treated (over 24h)
SA1746251682_LControl DCA-treated (over 24h)
SA1746263022_SControl DCA-treated (over 24h)
SA1746271277_SControl DCA-treated (over 24h)
SA1746281603_SControl DCA-treated (over 24h)
SA1746291356_SControl DCA-treated (over 24h)
SA1746301719_SControl DCA-treated (over 24h)
SA1746311277_RControl DCA-treated (over 24h)
SA1746323019_SControl DCA-treated (over 24h)
SA1746331603_RControl DCA-treated (over 24h)
SA1746341682_SControl DCA-treated (over 24h)
SA1746353022_RControl DCA-treated (over 24h)
SA1746363022_LControl DCA-treated (over 24h)
SA1746371603_LControl DCA-treated (over 24h)
SA1746381277_LControl DCA-treated (over 24h)
SA1746391356_LControl DCA-treated (over 24h)
SA1746401719_LControl DCA-treated (over 24h)
SA1746411401_LControl DCA-treated (over 24h)
SA1746421719_RControl DCA-treated (over 24h)
SA1746431269_LControl DCA-treated (over 24h)
SA1746443019_LControl DCA-treated (over 24h)
SA1746451682_RControl DCA-treated (over 24h)
SA1746461261_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746471329_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746481397_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746491727_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746501397_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746511448_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746521448_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746531727_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746541565_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746551428_SCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746561397_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746571261_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746581329_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746591428_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746601261_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746611329_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746621565_LCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746631428_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746641448_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746651727_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746661565_RCortisol-infused (1 g/kg/d from 115 to term) Control
SA1746671212_LCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746681445_SCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746691668_LCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746701642_SCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746711668_SCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746721642_RCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746731445_RCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746741668_RCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746751606_RCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746761642_LCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746771445_LCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746781212_SCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746791606_LCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746801212_RCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
SA1746811606_SCortisol-infused (1 g/kg/d from 115 to term) DCA-treated (over 24h)
Showing results 1 to 87 of 87
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