Summary of Study ST002064

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001307. The data can be accessed directly via it's Project DOI: 10.21228/M8S124 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

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Study IDST002064
Study TitleMetabolic impact of anticancer drugs Pd2Spermine and Cisplatin on the polar extracts of brain from healthy mice (part 1)
Study TypeNMR-based metabolomics
Study SummaryPlatinum (Pt(II)) drugs, e.g. cisplatin (cDDP), are some of the most used chemotherapeutic agents, yet tumor acquired resistance and high toxicity are still current drawbacks. Palladium (Pd(II))-complexes are alternatives due to similar metal coordination and promising cytotoxic properties. Metabolomics can measure the metabolic response of drug-exposed tissues, unveiling insight into drug mechanisms and new markers of drug efficacy/toxicity. The present 1H NMR metabolomics study aims to characterize the in vivo response of the impact of a Pd(II)-complex with polyamine spermine (Pd2Spm), compared to cDDP, on polar metabolism of brain from healthy mice at 1, 12 and 48 h post-injection times.
Institute
University of Aveiro
DepartmentDepartment of Chemistry and CICECO-Aveiro Institute of Materials
LaboratoryMetabolomics from Ana M. Gil
Last NameCarneiro
First NameTatiana João
AddressCampus Universitário de Santiago, Aveiro, Aveiro, 3810-193, Portugal
Emailtatiana.joao@ua.pt
Phone+351926369478
Submit Date2022-01-10
Num Groups9
Total Subjects45
Num Females45
Raw Data AvailableYes
Analysis Type DetailNMR
Release Date2022-02-02
Release Version1
Tatiana João Carneiro Tatiana João Carneiro
https://dx.doi.org/10.21228/M8S124
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Treatment_group
SA194181healthy_B_EA_B4_2_1_2Cisplatin_12h
SA194182healthy_B_EA_B4_3_1_2Cisplatin_12h
SA194183healthy_B_EA_B4_5_1_2Cisplatin_12h
SA194184healthy_B_EA_B4_1_1_2Cisplatin_12h
SA194185healthy_B_EA_B4_4_1_2Cisplatin_12h
SA194186healthy_B_EA_B2_2b_1_2Cisplatin_1h
SA194187healthy_B_EA_B2_4_1_2Cisplatin_1h
SA194188healthy_B_EA_B2_3_1_2Cisplatin_1h
SA194189healthy_B_EA_B2_1_1_2Cisplatin_1h
SA194190healthy_B_EA_B2_5_1_2Cisplatin_1h
SA194191healthy_B_EA_B6_1_1_2Cisplatin_48h
SA194192healthy_B_EA_B6_5_1_2Cisplatin_48h
SA194193healthy_B_EA_B6_4_1_2Cisplatin_48h
SA194194healthy_B_EA_B6_3_1_2Cisplatin_48h
SA194195healthy_B_EA_B6_2_1_2Cisplatin_48h
SA194196healthy_B_EA_A4_4_1_2Control_12h
SA194197healthy_B_EA_A4_3_1_2Control_12h
SA194198healthy_B_EA_A4_5b_1_2Control_12h
SA194199healthy_B_EA_A4_2b_1_2Control_12h
SA194200healthy_B_EA_A4_1b_1_2Control_12h
SA194201healthy_B_EA_A2_5_1_2Control_1h
SA194202healthy_B_EA_A2_2_1_2Control_1h
SA194203healthy_B_EA_A2_3_1_2Control_1h
SA194204healthy_B_EA_A2_4_1_2Control_1h
SA194205healthy_B_EA_A2_1_1_2Control_1h
SA194206healthy_B_EA_A6_3_1_2Control_48h
SA194207healthy_B_EA_A6_4b_1_2Control_48h
SA194208healthy_B_EA_A6_2_1_2Control_48h
SA194209healthy_B_EA_A6_1_1_2Control_48h
SA194210healthy_B_EA_C4_1_1_2Pd2Spermine_12h
SA194211healthy_B_EA_C4_3_1_2Pd2Spermine_12h
SA194212healthy_B_EA_C4_5_1_2Pd2Spermine_12h
SA194213healthy_B_EA_C4_2_1_2Pd2Spermine_12h
SA194214healthy_B_EA_C4_4_1_2Pd2Spermine_12h
SA194215healthy_B_EA_C2_2b_1_2Pd2Spermine_1h
SA194216healthy_B_EA_C2_5_1_2Pd2Spermine_1h
SA194217healthy_B_EA_C2_1b_1_2Pd2Spermine_1h
SA194218healthy_B_EA_C2_3_1_2Pd2Spermine_1h
SA194219healthy_B_EA_C2_4_1_2Pd2Spermine_1h
SA194220healthy_B_EA_C6_5_1_2Pd2Spermine_48h
SA194221healthy_B_EA_C6_4_1_2Pd2Spermine_48h
SA194222healthy_B_EA_C6_2_1_2Pd2Spermine_48h
SA194223healthy_B_EA_C6_1_1_2Pd2Spermine_48h
SA194224healthy_B_EA_C6_3_1_2Pd2Spermine_48h
Showing results 1 to 44 of 44
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