Summary of Study ST002065

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001307. The data can be accessed directly via it's Project DOI: 10.21228/M8S124 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Show all samples  
Download mwTab file (text)   |  Download mwTab file(JSON)
Study IDST002065
Study TitleMetabolic impact of anticancer drugs Pd2Spermine and Cisplatin on the nonpolar extracts of brain from healthy mice (part 2)
Study TypeNMR-based metabolomics
Study SummaryPlatinum (Pt(II)) drugs, e.g. cisplatin (cDDP), are some of the most used chemotherapeutic agents, yet tumor acquired resistance and high toxicity are still current drawbacks. Palladium (Pd(II))-complexes are alternatives due to similar metal coordination and promising cytotoxic properties. Metabolomics can measure the metabolic response of drug-exposed tissues, unveiling insight into drug mechanisms and new markers of drug efficacy/toxicity. The present 1H NMR metabolomics study aims to characterize the in vivo response of the impact of a Pd(II)-complex with polyamine spermine (Pd2Spm), compared to cDDP, on nonpolar metabolism of brain from healthy mice at 1, 12 and 48 h post-injection times.
Institute
University of Aveiro
DepartmentDepartment of Chemistry and CICECO-Aveiro Institute of Materials
LaboratoryMetabolomics from Ana M. Gil
Last NameCarneiro
First NameTatiana João
AddressCampus Universitário de Santiago, Aveiro, Aveiro, 3810-193, Portugal
Emailtatiana.joao@ua.pt
Phone+351 234 370 200
Submit Date2022-01-10
Num Groups9
Total Subjects45
Num Females45
Raw Data AvailableYes
Analysis Type DetailNMR
Release Date2022-02-02
Release Version1
Tatiana João Carneiro Tatiana João Carneiro
https://dx.doi.org/10.21228/M8S124
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Treatment_group
SA194225healthy_B_EL_B4_2_1_2Cisplatin_12h
SA194226healthy_B_EL_B4_3_1_2Cisplatin_12h
SA194227healthy_B_EL_B4_5_1_2Cisplatin_12h
SA194228healthy_B_EL_B4_1_1_2Cisplatin_12h
SA194229healthy_B_EL_B4_4_1_2Cisplatin_12h
SA194230healthy_B_EL_B2_2_1_2Cisplatin_1h
SA194231healthy_B_EL_B2_4_1_2Cisplatin_1h
SA194232healthy_B_EL_B2_3_1_2Cisplatin_1h
SA194233healthy_B_EL_B2_1_1_2Cisplatin_1h
SA194234healthy_B_EL_B2_5b_1_2Cisplatin_1h
SA194235healthy_B_EL_B6_1b_1_2Cisplatin_48h
SA194236healthy_B_EL_B6_5b_1_2Cisplatin_48h
SA194237healthy_B_EL_B6_4b_1_2Cisplatin_48h
SA194238healthy_B_EL_B6_3b_1_2Cisplatin_48h
SA194239healthy_B_EL_B6_2b_1_2Cisplatin_48h
SA194240healthy_B_EL_A4_4_1_2Control_12h
SA194241healthy_B_EL_A4_3b_1_2Control_12h
SA194242healthy_B_EL_A4_5_1_2Control_12h
SA194243healthy_B_EL_A4_2_1_2Control_12h
SA194244healthy_B_EL_A4_1b_1_2Control_12h
SA194245healthy_B_EL_A2_5_1_2Control_1h
SA194246healthy_B_EL_A2_2b_1_2Control_1h
SA194247healthy_B_EL_A2_3b_1_2Control_1h
SA194248healthy_B_EL_A2_4b_1_2Control_1h
SA194249healthy_B_EL_A2_1b_1_2Control_1h
SA194250healthy_B_EL_A6_3_1_2Control_48h
SA194251healthy_B_EL_A6_4_1_2Control_48h
SA194252healthy_B_EL_A6_2_1_2Control_48h
SA194253healthy_B_EL_A6_1_1_2Control_48h
SA194254healthy_B_EL_C4_1b_1_2Pd2Spermine_12h
SA194255healthy_B_EL_C4_3b_1_2Pd2Spermine_12h
SA194256healthy_B_EL_C4_5_1_2Pd2Spermine_12h
SA194257healthy_B_EL_C4_2_1_2Pd2Spermine_12h
SA194258healthy_B_EL_C4_4b_1_2Pd2Spermine_12h
SA194259healthy_B_EL_C2_2_1_2Pd2Spermine_1h
SA194260healthy_B_EL_C2_5_1_2Pd2Spermine_1h
SA194261healthy_B_EL_C2_1b_1_2Pd2Spermine_1h
SA194262healthy_B_EL_C2_3b_1_2Pd2Spermine_1h
SA194263healthy_B_EL_C2_4_1_2Pd2Spermine_1h
SA194264healthy_B_EL_C6_5_1_2Pd2Spermine_48h
SA194265healthy_B_EL_C6_4c_1_2Pd2Spermine_48h
SA194266healthy_B_EL_C6_2b_1_2Pd2Spermine_48h
SA194267healthy_B_EL_C6_1b_1_2Pd2Spermine_48h
SA194268healthy_B_EL_C6_3c_1_2Pd2Spermine_48h
Showing results 1 to 44 of 44
  logo