Summary of Study ST002067

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001309. The data can be accessed directly via it's Project DOI: 10.21228/M8HH60 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study ID	ST002067
Study Title	Time-Resolved Metabolomics of a Mouse Model of Ovarian High-Grade Serous Carcinoma (LC-MS)
Study Summary	The dismally-low survival rate of ovarian cancer patients diagnosed with high-grade serous carcinoma (HGSC) emphasizes the lack of effective screening strategies. One major obstacle is the limited knowledge of the underlying mechanisms of HGSC pathogenesis at very early stages. Here, we present the first 10-month time-resolved serum metabolic profile of a triple mutant (TKO) HGSC mouse model, along with the spatial lipidome profile of its entire reproductive system. A high-coverage liquid chromatography mass spectrometry-based metabolomics approach was applied to longitudinally-collected serum samples from both TKO and TKO control mice, tracking metabolome and lipidome changes from disease onset until death. Spatial lipid distributions within the reproductive system were also mapped via ultrahigh-resolution matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, and compared with serum lipid profiles for various lipid classes. Altogether, our results show that the remodeling of lipid and fatty acid metabolism, amino acid biosynthesis, TCA cycle and ovarian steroidogenesis are critical components of HGSC onset and development. These metabolic alterations are accompanied by changes in energy metabolism, mitochondrial and peroxisomal function, redox homeostasis, and inflammatory response, collectively supporting tumorigenesis.
Institute	Georgia Institute of Technology
Last Name	Sah
First Name	Samyukta
Address	901 Atlantic Dr NE, Atlanta, GA, 30332, USA
Email	ssah9@gatech.edu
Phone	574-678-0124
Submit Date	2022-01-26
Raw Data Available	Yes
Raw Data File Type(s)	raw(Thermo)
Analysis Type Detail	LC-MS
Release Date	2022-02-14
Release Version	1

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id	local_sample_id	Factor
SA194300	-	-
SA194301	C12_1	Control
SA194302	C7_14	Control
SA194303	C7_12	Control
SA194304	C12_2	Control
SA194305	C7_13	Control
SA194306	C12_4	Control
SA194307	C12_7	Control
SA194308	C12_6	Control
SA194309	C12_5	Control
SA194310	C7_11	Control
SA194311	C12_3	Control
SA194312	C7_9	Control
SA194313	C7_4	Control
SA194314	C7_3	Control
SA194315	C7_2	Control
SA194316	C7_1	Control
SA194317	C7_5	Control
SA194318	C7_6	Control
SA194319	C12_8	Control
SA194320	C7_8	Control
SA194321	C7_7	Control
SA194322	C7_10	Control
SA194323	C12_10	Control
SA194324	C8_12	Control
SA194325	C8_11	Control
SA194326	C8_10	Control
SA194327	C8_9	Control
SA194328	C8_13	Control
SA194329	C8_14	Control
SA194330	C9_3	Control
SA194331	C9_2	Control
SA194332	C9_1	Control
SA194333	C8_8	Control
SA194334	C8_7	Control
SA194335	C8_1	Control
SA194336	C12_12	Control
SA194337	C12_11	Control
SA194338	C6_11	Control
SA194339	C8_2	Control
SA194340	C8_3	Control
SA194341	C8_6	Control
SA194342	C8_5	Control
SA194343	C8_4	Control
SA194344	C12_9	Control
SA194345	C6_9	Control
SA194346	C4_14	Control
SA194347	C4_13	Control
SA194348	C4_12	Control
SA194349	C4_11	Control
SA194350	C4_15	Control
SA194351	C4_16	Control
SA194352	C5_3	Control
SA194353	C5_2	Control
SA194354	C5_1	Control
SA194355	C4_10	Control
SA194356	C4_9	Control
SA194357	C4_3	Control
SA194358	C4_2	Control
SA194359	C4_1	Control
SA194360	C3_9	Control
SA194361	C4_4	Control
SA194362	C4_5	Control
SA194363	C4_8	Control
SA194364	C4_7	Control
SA194365	C4_6	Control
SA194366	C5_4	Control
SA194367	C5_5	Control
SA194368	C6_4	Control
SA194369	C6_3	Control
SA194370	C6_2	Control
SA194371	C6_1	Control
SA194372	C6_5	Control
SA194373	C6_6	Control
SA194374	C9_4	Control
SA194375	C6_8	Control
SA194376	C6_7	Control
SA194377	C5_16	Control
SA194378	C5_15	Control
SA194379	C5_9	Control
SA194380	C5_8	Control
SA194381	C5_7	Control
SA194382	C5_6	Control
SA194383	C5_10	Control
SA194384	C5_11	Control
SA194385	C5_14	Control
SA194386	C5_13	Control
SA194387	C5_12	Control
SA194388	C6_10	Control
SA194389	C9_6	Control
SA194390	C14_10	Control
SA194391	C14_9	Control
SA194392	C14_8	Control
SA194393	C14_7	Control
SA194394	C14_11	Control
SA194395	C14_12	Control
SA194396	C15_2	Control
SA194397	C15_1	Control
SA194398	C14_13	Control
SA194399	C14_6	Control