Summary of Study ST002180

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001338. The data can be accessed directly via it's Project DOI: 10.21228/M8RX2S This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002180
Study TitleGlobal, distinctive and personal changes in molecular and microbial profiles induced by specific fibers in humans (Targeted)
Study SummaryDietary fibers act through the microbiome and improve cardiovascular health, metabolic disorders and cancer prevention. To understand health benefits of dietary fiber supplementation we investigated two popular purified fibers, arabinoxylan (AX) and long-chain inulin (LCI), and a mixture of five fibers. We present multi-omic signatures of metabolomics, lipidomics, proteomics, metagenomics, a cytokine panel and clinical measurements on healthy and insulin resistant participants. Each fiber is associated with fiber-dependent biochemical and microbial responses. AX consumption associates with a significant reduction in LDL and an increase in bile acids, contributing to its observed cholesterol reduction. LCI is associated with an increase in Bifidobacterium. However, at the highest LCI dose there is increased inflammation and elevation in the liver enzyme alanine aminotransferase. This study yields insights into the effects of fiber supplementation, it provides insights into mechanisms behind fiber induced cholesterol reduction, and it shows effects of individual, purified fibers on the microbiome.
Institute
Stanford University
Last NameLancaster
First NameSamuel
Address240 Pasteur Dr, BMI bldg 4400, Stanford California, 94305
Emailslancast@stanford.edu
Phone6126004033
Submit Date2022-03-18
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2022-07-15
Release Version1
Samuel Lancaster Samuel Lancaster
https://dx.doi.org/10.21228/M8RX2S
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Fiber Timepoint Sex
SA20927641Arabinoxylan 10 F
SA20927730Arabinoxylan 10 F
SA20927824Arabinoxylan 10 F
SA20927995Arabinoxylan 10 F
SA209280185Arabinoxylan 10 F
SA209281297Arabinoxylan 10 F
SA209282209Arabinoxylan 10 F
SA20928317Arabinoxylan 10 F
SA20928496Arabinoxylan 10 F
SA209285179Arabinoxylan 10 F
SA2092866Arabinoxylan 10 F
SA209287226Arabinoxylan 10 M
SA20928839Arabinoxylan 10 M
SA209289204Arabinoxylan 10 M
SA209290132Arabinoxylan 10 M
SA209291228Arabinoxylan 10 M
SA209292106Arabinoxylan 10 M
SA2092932Arabinoxylan 10 M
SA20929444Arabinoxylan 10 M
SA20929563Arabinoxylan 20 F
SA209296136Arabinoxylan 20 F
SA209297218Arabinoxylan 20 F
SA209298314Arabinoxylan 20 F
SA209299327Arabinoxylan 20 F
SA209300262Arabinoxylan 20 F
SA209301244Arabinoxylan 20 F
SA209302173Arabinoxylan 20 F
SA209303149Arabinoxylan 20 F
SA2093045Arabinoxylan 20 F
SA209305295Arabinoxylan 20 M
SA209306164Arabinoxylan 20 M
SA209307272Arabinoxylan 20 M
SA209308176Arabinoxylan 20 M
SA20930914Arabinoxylan 20 M
SA209310139Arabinoxylan 20 M
SA209311311Arabinoxylan 20 M
SA20931211Arabinoxylan 20 M
SA209313231Arabinoxylan 30 F
SA209314276Arabinoxylan 30 F
SA209315183Arabinoxylan 30 F
SA209316284Arabinoxylan 30 F
SA20931780Arabinoxylan 30 F
SA209318102Arabinoxylan 30 F
SA209319215Arabinoxylan 30 F
SA20932054Arabinoxylan 30 F
SA209321275Arabinoxylan 30 F
SA20932261Arabinoxylan 30 F
SA209323155Arabinoxylan 30 M
SA209324300Arabinoxylan 30 M
SA20932584Arabinoxylan 30 M
SA209326165Arabinoxylan 30 M
SA209327343Arabinoxylan 30 M
SA209328238Arabinoxylan 30 M
SA209329206Arabinoxylan 30 M
SA209330250Arabinoxylan 30 M
SA209331153Arabinoxylan Baseline F
SA209332192Arabinoxylan Baseline F
SA209333128Arabinoxylan Baseline F
SA209334211Arabinoxylan Baseline F
SA209335222Arabinoxylan Baseline F
SA209336328Arabinoxylan Baseline F
SA20933771Arabinoxylan Baseline F
SA20933855Arabinoxylan Baseline F
SA209339126Arabinoxylan Baseline F
SA209340116Arabinoxylan Baseline F
SA20934145Arabinoxylan Baseline M
SA209342287Arabinoxylan Baseline M
SA20934358Arabinoxylan Baseline M
SA209344245Arabinoxylan Baseline M
SA209345345Arabinoxylan Baseline M
SA209346320Arabinoxylan Baseline M
SA209347154Arabinoxylan Baseline M
SA209348335Arabinoxylan Baseline M
SA20934948Arabinoxylan Baseline M
SA209350279Arabinoxylan Month 1 M
SA209351158Arabinoxylan Month 1 M
SA209352325Arabinoxylan Month 2 M
SA209353263Arabinoxylan Month 2 M
SA209354273Arabinoxylan Month 3 M
SA209355271Arabinoxylan Month 3 M
SA20935687Arabinoxylan Washout D10 F
SA209357249Arabinoxylan Washout D10 F
SA209358348Arabinoxylan Washout D10 F
SA209359101Arabinoxylan Washout D10 F
SA209360180Arabinoxylan Washout D10 F
SA209361234Arabinoxylan Washout D10 F
SA209362170Arabinoxylan Washout D10 F
SA209363347Arabinoxylan Washout D10 F
SA20936426Arabinoxylan Washout D10 F
SA209365135Arabinoxylan Washout D10 F
SA209366137Arabinoxylan Washout D10 M
SA209367243Arabinoxylan Washout D10 M
SA209368292Arabinoxylan Washout D10 M
SA20936988Arabinoxylan Washout D10 M
SA209370354Arabinoxylan Washout D10 M
SA209371349Arabinoxylan Washout D10 M
SA20937251Arabinoxylan Washout D10 M
SA209373144Arabinoxylan Washout D30 M
SA209374264Arabinoxylan Washout D3 F
SA209375117Arabinoxylan Washout D3 F
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