Summary of Study ST002290
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001307. The data can be accessed directly via it's Project DOI: 10.21228/M8S124 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002290 |
| Study Title | Metabolic impact of anticancer drugs Pd2Spermine and Cisplatin on the polar metabolome of brain from cell-derived xenograft mouse model of Triple-Negative Breast Cancer (part 1) |
| Study Type | NMR-based metabolomics |
| Study Summary | Platinum (Pt(II)) drugs, e.g. cisplatin (cDDP), are some of the most used chemotherapeutic agents, yet tumor acquired resistance and high toxicity are still current drawbacks. Palladium (Pd(II))-complexes are alternatives due to similar metal coordination and promising cytotoxic properties. Metabolomics can measure the metabolic response of drug-exposed tissues, unveiling insight into drug mechanisms and new markers of drug efficacy/toxicity. The present 1H NMR metabolomics study aims to characterize the in vivo response of the impact of a Pd(II)-complex with polyamine spermine (Pd2Spm), compared to cDDP, on polar metabolism of brain from cell-derived xenograft mouse model of Triple-Negative Breast Cancer. |
| Institute | University of Aveiro |
| Department | Department of Chemistry and CICECO-Aveiro Institute of Materials |
| Laboratory | Metabolomics from Ana M. Gil |
| Last Name | Carneiro |
| First Name | Tatiana João |
| Address | Campus Universitário de Santiago, Aveiro, Aveiro, 3810-193, Portugal |
| tatiana.joao@ua.pt | |
| Phone | +351926369478 |
| Submit Date | 2022-09-14 |
| Num Groups | 3 |
| Total Subjects | 22 |
| Num Females | 22 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | fid |
| Analysis Type Detail | NMR |
| Release Date | 2022-12-15 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)
| mb_sample_id | local_sample_id | Treatment_group |
|---|---|---|
| SA220012 | xeno_B_EA_A_24_1_2 | Cisplatin-treated |
| SA220013 | xeno_B_EA_A_16b_1_2 | Cisplatin-treated |
| SA220014 | xeno_B_EA_A_25b_1_2 | Cisplatin-treated |
| SA220015 | xeno_B_EA_A_32b_1_2 | Cisplatin-treated |
| SA220016 | xeno_B_EA_A_33_1_2 | Cisplatin-treated |
| SA220017 | xeno_B_EA_A_14_1_2 | Cisplatin-treated |
| SA220018 | xeno_B_EA_A_28b_1_2 | Cisplatin-treated |
| SA220019 | xeno_B_EA_A_7_1_2 | Cisplatin-treated |
| SA220020 | xeno_B_EA_C_17_1_2 | Control |
| SA220021 | xeno_B_EA_C_20_1_2 | Control |
| SA220022 | xeno_B_EA_C_26_1_2 | Control |
| SA220023 | xeno_B_EA_C_29_1_2 | Control |
| SA220024 | xeno_B_EA_C_27_1_2 | Control |
| SA220025 | xeno_B_EA_C_11_1_2 | Control |
| SA220026 | xeno_B_EA_B_23b_1_2 | Pd2Spm-treated |
| SA220027 | xeno_B_EA_B_30b_1_2 | Pd2Spm-treated |
| SA220028 | xeno_B_EA_B_22b_1_2 | Pd2Spm-treated |
| SA220029 | xeno_B_EA_B_10_1_2 | Pd2Spm-treated |
| SA220030 | xeno_B_EA_B_8_1_2 | Pd2Spm-treated |
| SA220031 | xeno_B_EA_B_13_1_2 | Pd2Spm-treated |
| SA220032 | xeno_B_EA_B_18_1_2 | Pd2Spm-treated |
| SA220033 | xeno_B_EA_B_19_1_2 | Pd2Spm-treated |
| Showing results 1 to 22 of 22 |
