Summary of Study ST002293

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001307. The data can be accessed directly via it's Project DOI: 10.21228/M8S124 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002293
Study TitleMetabolic impact of anticancer drugs Pd2Spermine and Cisplatin on the lipophilic metabolome of brain from cell-derived xenograft mouse model of Triple-Negative Breast Cancer (part 2)
Study TypeNMR-based metabolomics
Study SummaryPlatinum (Pt(II)) drugs, e.g. cisplatin (cDDP), are some of the most used chemotherapeutic agents, yet tumor acquired resistance and high toxicity are still current drawbacks. Palladium (Pd(II))-complexes are alternatives due to similar metal coordination and promising cytotoxic properties. Metabolomics can measure the metabolic response of drug-exposed tissues, unveiling insight into drug mechanisms and new markers of drug efficacy/toxicity. The present 1H NMR metabolomics study aims to characterize the in vivo response of the impact of a Pd(II)-complex with polyamine spermine (Pd2Spm), compared to cDDP, on nonpolar metabolism of brain from cell-derived xenograft mouse model of Triple-Negative Breast Cancer.
Institute
University of Aveiro
DepartmentDepartment of Chemistry and CICECO-Aveiro Institute of Materials
LaboratoryMetabolomics from Ana M. Gil
Last NameCarneiro
First NameTatiana João
AddressCampus Universitário de Santiago, Aveiro, Aveiro, 3810-193, Portugal
Emailtatiana.joao@ua.pt
Phone+351 234 370 200
Submit Date2022-09-14
Num Groups3
Total Subjects21
Num Females21
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2022-12-15
Release Version1
Tatiana João Carneiro Tatiana João Carneiro
https://dx.doi.org/10.21228/M8S124
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Treatment_group
SA220308xeno_B_EL_A_24_1_2Cisplatin-treated
SA220309xeno_B_EL_A_25b_1_2Cisplatin-treated
SA220310xeno_B_EL_A_33b_1_2Cisplatin-treated
SA220311xeno_B_EL_A_16b_1_2Cisplatin-treated
SA220312xeno_B_EL_A_32b_1_2Cisplatin-treated
SA220313xeno_B_EL_A_28b_1_2Cisplatin-treated
SA220314xeno_B_EL_A_14_1_2Cisplatin-treated
SA220315xeno_B_EL_A_7_1_2Cisplatin-treated
SA220316xeno_B_EL_C_20_1_2Control
SA220317xeno_B_EL_C_26_1_2Control
SA220318xeno_B_EL_C_27_1_2Control
SA220319xeno_B_EL_C_17_1_2Control
SA220320xeno_B_EL_C_29_1_2Control
SA220321xeno_B_EL_B_23b_1_2Pd2Spm-treated
SA220322xeno_B_EL_B_30b_1_2Pd2Spm-treated
SA220323xeno_B_EL_B_22c_1_2Pd2Spm-treated
SA220324xeno_B_EL_B_10b_1_2Pd2Spm-treated
SA220325xeno_B_EL_B_8b_1_2Pd2Spm-treated
SA220326xeno_B_EL_B_13b_1_2Pd2Spm-treated
SA220327xeno_B_EL_B_18b_1_2Pd2Spm-treated
SA220328xeno_B_EL_B_19b_1_2Pd2Spm-treated
Showing results 1 to 21 of 21
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