Summary of Study ST002295
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001307. The data can be accessed directly via it's Project DOI: 10.21228/M8S124 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002295 |
| Study Title | Metabolic impact of anticancer drugs Pd2Spermine and Cisplatin on the lipophilic metabolome of liver from cell-derived xenograft mouse model of Triple-Negative Breast Cancer (part 2) |
| Study Type | NMR-based metabolomics |
| Study Summary | Platinum (Pt(II)) drugs, e.g. cisplatin (cDDP), are some of the most used chemotherapeutic agents, yet tumor acquired resistance and high toxicity are still current drawbacks. Palladium (Pd(II))-complexes are alternatives due to similar metal coordination and promising cytotoxic properties. Metabolomics can measure the metabolic response of drug-exposed tissues, unveiling insight into drug mechanisms and new markers of drug efficacy/toxicity. The present 1H NMR metabolomics study aims to characterize the in vivo response of the impact of a Pd(II)-complex with polyamine spermine (Pd2Spm), compared to cDDP, on lipophilic metabolism of liver from cell-derived xenograft mouse model of Triple-Negative Breast Cancer. |
| Institute | University of Aveiro |
| Department | Department of Chemistry and CICECO-Aveiro Institute of Materials |
| Laboratory | Metabolomics from Ana M. Gil |
| Last Name | Carneiro |
| First Name | Tatiana João |
| Address | Campus Universitário de Santiago, Aveiro, Aveiro, 3810-193, Portugal |
| tatiana.joao@ua.pt | |
| Phone | +351 234 370 200 |
| Submit Date | 2022-09-14 |
| Num Groups | 3 |
| Total Subjects | 22 |
| Num Females | 22 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | fid |
| Analysis Type Detail | NMR |
| Release Date | 2022-12-15 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)
| mb_sample_id | local_sample_id | Treatment_group |
|---|---|---|
| SA220351 | xeno_L_EL_A_24b_1_2 | Cisplatin-treated |
| SA220352 | xeno_L_EL_A_16_1_2 | Cisplatin-treated |
| SA220353 | xeno_L_EL_A_25_1_2 | Cisplatin-treated |
| SA220354 | xeno_L_EL_A_32b_1_2 | Cisplatin-treated |
| SA220355 | xeno_L_EL_A_33b_1_2 | Cisplatin-treated |
| SA220356 | xeno_L_EL_A_14_1_2 | Cisplatin-treated |
| SA220357 | xeno_L_EL_A_28b_1_2 | Cisplatin-treated |
| SA220358 | xeno_L_EL_A_7_1_2 | Cisplatin-treated |
| SA220359 | xeno_L_EL_C_17_1_2 | Control |
| SA220360 | xeno_L_EL_C_20b_1_2 | Control |
| SA220361 | xeno_L_EL_C_26b_1_2 | Control |
| SA220362 | xeno_L_EL_C_29b_1_2 | Control |
| SA220363 | xeno_L_EL_C_27b_1_2 | Control |
| SA220364 | xeno_L_EL_C_11_1_2 | Control |
| SA220365 | xeno_L_EL_B_23b_1_2 | Pd2Spm-treated |
| SA220366 | xeno_L_EL_B_30b_1_2 | Pd2Spm-treated |
| SA220367 | xeno_L_EL_B_22b_1_2 | Pd2Spm-treated |
| SA220368 | xeno_L_EL_B_10b_1_2 | Pd2Spm-treated |
| SA220369 | xeno_L_EL_B_8b_1_2 | Pd2Spm-treated |
| SA220370 | xeno_L_EL_B_13c_1_2 | Pd2Spm-treated |
| SA220371 | xeno_L_EL_B_18b_1_2 | Pd2Spm-treated |
| SA220372 | xeno_L_EL_B_19b_1_2 | Pd2Spm-treated |
| Showing results 1 to 22 of 22 |
