Summary of Study ST003015

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001876. The data can be accessed directly via it's Project DOI: 10.21228/M87426 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003015
Study TitleNMR- and MS-based omics reveal characteristic metabolome atlas and optimize biofluid earlydiagnostic biomarkers for esophageal squamous cell carcinoma (part-Ⅰ)
Study SummaryMetabolic changes precede malignant histology. However, it remains unclear whether detectable characteristic metabolome exists in esophageal squamous cell carcinoma (ESCC) tissues and biofluids for early diagnosis. We conducted NMR- and MS-based metabolomics on 1,153 matched ESCC tissues, normal mucosae, pre- and one-week post-operative sera and urines from 560 participants across three hospitals, with machine learning, logistic regression and WGCNA. Aberrations in 'alanine, aspartate and glutamate metabolism' proved to be prevalent throughout the ESCC evolution, and were reflected in 16 serum and 10 urine metabolic signatures that were consistently identified by NMR and MS in both discovery and validation sets. NMR-based simplified panels of any five serum or urine metabolites outperformed clinical serological tumor markers (AUC = 0.984 and 0.930, respectively), and were effective in distinguishing early-stage ESCC in test set (serum accuracy = 0.994, urine accuracy = 0.879). Collectively, NMR-based biofluid screening can reveal characteristic metabolic events of ESCC and be feasible for early detection (ChiCTR2300073613).
Institute
Radiology Department, Second Affiliated Hospital, Shantou University Medical College
Last NameLin
First NameYan
AddressNo. 69, Dongxia North Road, Shantou, Guangdong, China
Email994809889@qq.com
Phone+86 18823992148
Submit Date2023-12-16
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2024-02-08
Release Version1
Yan Lin Yan Lin
https://dx.doi.org/10.21228/M87426
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Fator
SA32746320220725.73.fid#73Normal tissue
SA32746420220725.74.fid#74Normal tissue
SA32746520220725.72.fid#72Normal tissue
SA32746620220725.71.fid#71Normal tissue
SA32746720220725.70.fid#70Normal tissue
SA32746820220725.75.fid#75Normal tissue
SA32746920220725.77.fid#77Normal tissue
SA32747020220725.80.fid#80Normal tissue
SA32747120220725.81.fid#81Normal tissue
SA32747220220725.79.fid#79Normal tissue
SA32747320220725.78.fid#78Normal tissue
SA32747420220725.69.fid#69Normal tissue
SA32747520220725.76.fid#76Normal tissue
SA32747620220725.68.fid#68Normal tissue
SA32747720220725.60.fid#60Normal tissue
SA32747820220725.61.fid#61Normal tissue
SA32747920220725.59.fid#59Normal tissue
SA32748020220725.58.fid#58Normal tissue
SA32748120220725.57.fid#57Normal tissue
SA32748220220725.62.fid#62Normal tissue
SA32748320220725.63.fid#63Normal tissue
SA32748420220725.67.fid#67Normal tissue
SA32748520220725.66.fid#66Normal tissue
SA32748620220725.65.fid#65Normal tissue
SA32748720220725.64.fid#64Normal tissue
SA32748820220725.82.fid#82Normal tissue
SA32748920220725.84.fid#84Normal tissue
SA32749020220725.100.fid#100Normal tissue
SA32749120220725.101.fid#101Normal tissue
SA32749220220725.99.fid#99Normal tissue
SA32749320220725.98.fid#98Normal tissue
SA32749420220725.97.fid#97Normal tissue
SA32749520220725.102.fid#102Normal tissue
SA32749620220725.103.fid#103Normal tissue
SA32749720220725.107.fid#107Normal tissue
SA32749820220725.108.fid#108Normal tissue
SA32749920220725.106.fid#106Normal tissue
SA32750020220725.105.fid#105Normal tissue
SA32750120220725.104.fid#104Normal tissue
SA32750220220725.96.fid#96Normal tissue
SA32750320220725.95.fid#95Normal tissue
SA32750420220725.87.fid#87Normal tissue
SA32750520220725.88.fid#88Normal tissue
SA32750620220725.86.fid#86Normal tissue
SA32750720220725.85.fid#85Normal tissue
SA32750820220725.56.fid#56Normal tissue
SA32750920220725.89.fid#89Normal tissue
SA32751020220725.90.fid#90Normal tissue
SA32751120220725.94.fid#94Normal tissue
SA32751220220725.93.fid#93Normal tissue
SA32751320220725.92.fid#92Normal tissue
SA32751420220725.91.fid#91Normal tissue
SA32751520220725.83.fid#83Normal tissue
SA32751620220725.55.fid#55Normal tissue
SA32751720220725.19.fid#19Tumor tissue
SA32751820220725.20.fid#20Tumor tissue
SA32751920220725.18.fid#18Tumor tissue
SA32752020220725.17.fid#17Tumor tissue
SA32752120220725.16.fid#16Tumor tissue
SA32752220220725.21.fid#21Tumor tissue
SA32752320220725.22.fid#22Tumor tissue
SA32752420220725.26.fid#26Tumor tissue
SA32752520220725.27.fid#27Tumor tissue
SA32752620220725.25.fid#25Tumor tissue
SA32752720220725.24.fid#24Tumor tissue
SA32752820220725.23.fid#23Tumor tissue
SA32752920220725.15.fid#15Tumor tissue
SA32753020220725.14.fid#14Tumor tissue
SA32753120220725.5.fid#5Tumor tissue
SA32753220220725.6.fid#6Tumor tissue
SA32753320220725.4.fid#4Tumor tissue
SA32753420220725.3.fid#3Tumor tissue
SA32753520220725.2.fid#2Tumor tissue
SA32753620220725.7.fid#7Tumor tissue
SA32753720220725.8.fid#8Tumor tissue
SA32753820220725.12.fid#12Tumor tissue
SA32753920220725.13.fid#13Tumor tissue
SA32754020220725.11.fid#11Tumor tissue
SA32754120220725.10.fid#10Tumor tissue
SA32754220220725.9.fid#9Tumor tissue
SA32754320220725.28.fid#28Tumor tissue
SA32754420220725.29.fid#29Tumor tissue
SA32754520220725.46.fid#46Tumor tissue
SA32754620220725.47.fid#47Tumor tissue
SA32754720220725.45.fid#45Tumor tissue
SA32754820220725.44.fid#44Tumor tissue
SA32754920220725.43.fid#43Tumor tissue
SA32755020220725.48.fid#48Tumor tissue
SA32755120220725.49.fid#49Tumor tissue
SA32755220220725.53.fid#53Tumor tissue
SA32755320220725.54.fid#54Tumor tissue
SA32755420220725.52.fid#52Tumor tissue
SA32755520220725.51.fid#51Tumor tissue
SA32755620220725.50.fid#50Tumor tissue
SA32755720220725.42.fid#42Tumor tissue
SA32755820220725.41.fid#41Tumor tissue
SA32755920220725.33.fid#33Tumor tissue
SA32756020220725.34.fid#34Tumor tissue
SA32756120220725.32.fid#32Tumor tissue
SA32756220220725.31.fid#31Tumor tissue
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