Summary of Study ST003102

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001925. The data can be accessed directly via it's Project DOI: 10.21228/M8WM7T This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003102
Study TitleCellular adaptation to cancer therapy occurs by progressive state transitions along a resistance continuum
Study SummaryRecent research has shed light on the role of non-genetic plasticity in transient drug tolerance and the acquisition of stable resistance. However, the dynamics of cell state transitions occurring in the adaptation to cancer therapies remain elusive and require a systems-level longitudinal framework. Here we demonstrate that resistance develops through trajectories of cell state transitions accompanied by a progressive increase in cell fitness, which we denote the ‘resistance continuum’. This cellular adaptation involves a step-wise assembly of gene expression programs and epigenetically reinforced cell states underpinned by phenotypic plasticity stress adaptation and metabolic reprogramming. Through systematic genetic perturbations, we identify an acquisition of progressive metabolic dependencies, exposing a spectrum of vulnerabilities that can be potentially exploited therapeutically. The concept of the resistance continuum highlights the dynamic nature of cellular adaptation and calls for complementary therapies directed at the mechanisms underlying adaptive cell state transitions.
Institute
NYU Langone Health
Last NameStarvaggi Franca
First NameGustavo
Address430 East 29th Street, NY NY 10016
EmailGustavo.StarvaggiFranca@nyulangone.org
Phone6465015151
Submit Date2024-02-13
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailLC-MS
Release Date2024-04-02
Release Version1
Gustavo Starvaggi Franca Gustavo Starvaggi Franca
https://dx.doi.org/10.21228/M8WM7T
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Cultured cells; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sample source Treatment
SA333491S25059Ovarian cancer cells C
SA333492S25061Ovarian cancer cells C
SA333493S25060Ovarian cancer cells C
SA333494S25064Ovarian cancer cells C_drug
SA333495S25062Ovarian cancer cells C_drug
SA333496S25063Ovarian cancer cells C_drug
SA333497S25067Ovarian cancer cells T320
SA333498S25065Ovarian cancer cells T320
SA333499S25066Ovarian cancer cells T320
SA333500S25070Ovarian cancer cells T320_drug
SA333501S25069Ovarian cancer cells T320_drug
SA333502S25068Ovarian cancer cells T320_drug
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