Summary of Study ST000285
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000227. The data can be accessed directly via it's Project DOI: 10.21228/M89P43 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000285 |
| Study Title | NMR-based Metabolomics for CRC Diagnosis |
| Study Type | Disease Diagnosis |
| Study Summary | Despite the fact that colorectal cancer (CRC) is one of the most prevalent and deadly cancers in the world, the development of improved and robust biomarkers to enable screening, surveillance, and therapy monitoring of CRC continues to be evasive. In particular, patients with colon polyps are at higher risk of developing colon cancer; however, noninvasive methods to identify these patients suffer from poor performance. In consideration of the challenges involved in identifying metabolite biomarkers in individuals with high risk for colon cancer, we have investigated NMR-based metabolite profiling in combination with numerous demographic parameters to investigate the ability of serum metabolites to differentiate polyp/CRC patients from healthy subjects. We also investigated the effect of disease risk on different groups of biologically related metabolites. Our study may explain some of the challenges and promise a novel avenue for future metabolite profiling methodologies. |
| Institute | University of Washington |
| Department | Anesthesiology and Pain Medicine |
| Laboratory | Northwest Metabolomics Research Center |
| Last Name | Gu |
| First Name | Haiwei |
| Address | 850 Republican St., Seattle WA 98109 |
| draftery@uw.edu | |
| Phone | 206-543-9709 |
| Submit Date | 2016-12-17 |
| Num Groups | 3 |
| Total Subjects | 233 |
| Analysis Type Detail | NMR |
| Release Date | 2015-12-21 |
| Release Version | 1 |
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Project:
| Project ID: | PR000227 |
| Project DOI: | doi: 10.21228/M89P43 |
| Project Title: | NMR-based Metabolomics for CRC Diagnosis |
| Project Type: | NMR study |
| Project Summary: | Despite the fact that colorectal cancer (CRC) is one of the most prevalent and deadly cancers in the world, the development of improved and robust biomarkers to enable screening, surveillance, and therapy monitoring of CRC continues to be evasive. In particular, patients with colon polyps are at higher risk of developing colon cancer; however, noninvasive methods to identify these patients suffer from poor performance. In consideration of the challenges involved in identifying metabolite biomarkers in individuals with high risk for colon cancer, we have investigated NMR-based metabolite profiling in combination with numerous demographic parameters to investigate the ability of serum metabolites to differentiate polyp/CRC patients from healthy subjects. We also investigated the effect of disease risk on different groups of biologically related metabolites. Our study may explain some of the challenges and promise a novel avenue for future metabolite profiling methodologies. |
| Institute: | University of Washington |
| Department: | Anesthesiology and Pain Medicine |
| Laboratory: | Northwest Metabolomics Research Center |
| Last Name: | Raftery |
| First Name: | Daniel |
| Address: | 850 Republican St., Seattle WA 98109 |
| Email: | draftery@uw.edu |
| Phone: | 206-543-9709 |
