Summary of Study ST000341

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000273. The data can be accessed directly via it's Project DOI: 10.21228/M8H30K This work is supported by NIH grant, U2C- DK119886.


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Study IDST000341
Study TitleMethylation in mouse lymphomas
Study TypeCase-Control (3 groups)
Study SummaryWe want to determine if there is a difference in the DNA methylation status of liver and Bone marrow in Cbs-/- mice under + or - ZnH20.
University of Florida
LaboratoryKruger - Cancer Biology
Last NameLee
First NameHyung-Ok
AddressFox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111
Submit Date2016-01-28
Num Groups4
Total Subjects24
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2017-01-28
Release Version1
Hyung-Ok Lee Hyung-Ok Lee application/zip

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Project ID:PR000273
Project DOI:doi: 10.21228/M8H30K
Project Title:Methylation in mouse liver
Project Type:DNA Methylation
Project Summary:We are interested in knowing whether elevated total homocysteine affects the level of DNA methylation liver cells and Bone Marrow in our inducible mouse model of hyperhomocysteinemia. To answer this question, we will use our Tg-hCBS Cbs-/- mouse. This mouse lacks the endogenous mouse CBS gene and instead contains a human CBS cDNA transgene that is under control of a zinc inducible MT-1 promoter. We will send you DNA isolated from the livers and Bone Marrow of twelve animals, six of which that were uninduced and six that were induced by treatment with zinc water.
Institute:Fox Chase Cancer Center
Department:Cancer Biology
Last Name:Kruger
First Name:Warren
Address:Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111
Funding Source:R01GM098772-04