Summary of Study ST000686

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000485. The data can be accessed directly via it's Project DOI: 10.21228/M8C89G This work is supported by NIH grant, U2C- DK119886.


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Study IDST000686
Study TitleLipodomics and Gestational bisphenol A (BPA) exposure
Study TypeMS analysis
Study SummaryGestational BPA exposure in sheep induces metabolic phenotype in sheep characterized by peripheral insulin resistance and increased adipocyte size. Because insulin sensitivity can be regulated by various agents including free fatty acids (FFA), we hypothesize that gestational BPA exposure alters circulating FFA inducing dyslipidemia, a marker of metabolic disorder. Because saturated FFA is associated with insulin resistance, determination of the FFA profile in these species aid in understanding the underlying mechanism. Additionally, because of the non-monotonic nature of responses to BPA exposure dose response studies are also needed. This study will therefore assess plasma lipid profile in sheep exposed to three different doses of BPA prenatally and compared with untreated control animals
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Phone(734) 232-8175
Submit Date2016-07-05
Num Groups4
Total Subjects28
Study CommentsMetabolic disorders such as obesity and diabetes are currently widespread with epidemic proportions. Recent studies have implicated that these disorders have developmental basis due to maternal exposure to adverse insults including endocrine disruptors such as Bisphenol A (BPA). As BPA is present in maternal serum, amniotic fluid, cord blood taken at birth, placenta, colostrum and breast milk suggests that BPA has developmental impacts. In fact developmental BPA exposure have been linked to intrauterine growth restriction and low birth weight offspring, risk factors for adult cardiometabolic abnormalities. Animal models are helpful to study the effect of developmental BPA exposure and determine associated mechanisms.
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman application/zip

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Project ID:PR000485
Project DOI:doi: 10.21228/M8C89G
Project Title:Impact of prenatal bisphenol A (BPA) on the lipidomics of the female sheep
Project Type:MS analysis
Project Summary:Gestational exposure of bisphenol A in female sheep induces metabolic phenotype and the impact of BPA on lipidomics is being assessed to determine the mechanism that leads to altered insulin sensitivity
Institute:University of Michigan
Department:Environmental Health Sciences
Laboratory:Padmanabhan Lab
Last Name:Padmanabhan
First Name:Vasantha
Address:Ann Arbor, MI