Summary of Study ST000902
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000461. The data can be accessed directly via it's Project DOI: 10.21228/M8G609 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000902 |
| Study Title | Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice - Liver (part VI) |
| Study Summary | Characterization and analysis of metabolomic, proteomic and metabolic profiles of C57/Bl6N mice fed various high fat diets |
| Institute | University of California, Davis |
| Last Name | Yang |
| First Name | Jun |
| Address | 207 Everson Hall, Shields One Ave, Davis CA 95616 |
| junyang@ucdavis.edu | |
| Phone | 5307525109 |
| Submit Date | 2017-07-26 |
| Analysis Type Detail | LC-MS |
| Release Date | 2017-11-26 |
| Release Version | 1 |
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Project:
| Project ID: | PR000461 |
| Project DOI: | doi: 10.21228/M8G609 |
| Project Title: | Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice |
| Project Summary: | In this study we have compared the metabolic effects of conventional soybean oil to those of genetically modified Plenish soybean oil, that is low in linoleic acid and high in oleic acid. This work builds on our previous study showing that soybean oil, rich in polyunsaturated fats, is more obesogenic and diabetogenic than coconut oil, rich in saturated fats (PMID: 26200659). Here, in order to elucidate the mechanisms responsible for soybean oil induced obesity, we have performed the first ever metabolomics (in plasma and liver) and proteomics on the livers of mice fed the two soybean oil diets (plus those fed a high coconut oil and Viv chow diet). Our results show that the new high oleic soybean oil induces less obesity and adiposity than conventional soybean oil, but can cause hepatomegaly and liver dysfunction. Metabolomic analysis reveals that the hepatic and plasma metabolic profiles differ considerably between the two soybean oils. Hepatic C18 oxylipin metabolites of omega-6 (ω6) and omega-3 (ω3) fatty acids (linoleic and α-linolenic acid, respectively) in the cytochrome P450/soluble epoxide hydrolase pathway were found to correlate positively with obesity. |
| Institute: | University of California, Riverside |
| Department: | Cell Biology and Neuroscience |
| Last Name: | Sladek |
| First Name: | Frances |
| Address: | 2115 Biological Sciences Building,University of California, Riverside, CA 92521-0314 |
| Email: | frances.sladek@ucr.edu |
| Phone: | 951-827-2264 |
