Summary of Study ST002133
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001351. The data can be accessed directly via it's Project DOI: 10.21228/M83699 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002133 |
| Study Title | Metabolite variation in the blood serum of HIV carrier patients treated with effervescent glutamine |
| Study Type | Liquid NMR experiments |
| Study Summary | It was demonstrated that effervescent glutamine supplementation in people living with HIV/AIDS increased the amount of CD4+ T lymphocytes. , decreased the serum levels of biomarkers of inflammation, and introduced health benefits. Herein, NMR spectroscopy was applied to evaluate if oral ingestion of glutamine (12.5 g) for 30 days can be measured through serum metabolite variations and if the reported benefits might correlate to small metabolites' changes in a chosen cohort of individuals. The HIV/AIDS group has been carefully selected and studied before and after the 30-days of supplementation with the glutamine, together with the matched non-HIV carrier patients' group. The group of HIV/AIDS individuals presented lower (p < 0.05) levels of choline, creatine, pyruvate, glutamate, lysine, and tyrosine when compared to the non-HIV carrier patients. On the other hand, serum concentrations of glucose, lipids, lactate, glutamine, phenylalanine, and threonine were higher (p < 0.05) in HIV/AIDS individuals. The variation in metabolites as a result of treatment with glutamine is consistent with the improvements observed in these patients and may lead us to suggest the introduction of the effervescent glutamine supplementation to antiretroviral therapies in people living with HIV/AIDS. |
| Institute | University of Campinas |
| Department | Organic Chemistry |
| Laboratory | Biological Chemistry Lab |
| Last Name | MARTINS |
| First Name | LUCAS |
| Address | Rua Josué de Castro, s/n - Cidade Universitária, Campinas - SP, 13083-970 |
| lgmartins1984@gmail.com | |
| Phone | +5519992947044 |
| Submit Date | 2022-03-31 |
| Num Groups | 3 |
| Total Subjects | 24 |
| Num Males | 10 |
| Num Females | 14 |
| Study Comments | Crossover study |
| Raw Data Available | Yes |
| Raw Data File Type(s) | fid |
| Analysis Type Detail | NMR |
| Release Date | 2022-04-27 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
| Project ID: | PR001351 |
| Project DOI: | doi: 10.21228/M83699 |
| Project Title: | Untargeted metabolomics of HIV carrier patients |
| Project Type: | NMR-based metabolomics |
| Project Summary: | Analysis of metabolite variation in HIV carrier patients blood serum in response to treatment with effervescent glutamine. |
| Institute: | University of Campinas |
| Department: | Organic Chemistry |
| Laboratory: | Biological Chemistry Lab |
| Last Name: | Martins |
| First Name: | Lucas |
| Address: | Cidade Universitário Zeferino Vaz, Campinas, SP, Brazil |
| Email: | lgmartins1984@gmail.com |
| Phone: | +5519992947044 |
| Funding Source: | FAPESP, INCT-Bio |
