Summary of Study ST002135
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001352. The data can be accessed directly via it's Project DOI: 10.21228/M8ZD7C This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002135 |
| Study Title | Alignment and Analysis of a Disparately Acquired Multi-Batch Metabolomics Study of Maternal Pregnancy Samples. (Part 2) |
| Study Summary | This is an untargeted RPLC-MS metabolomics study of mother-infant pairs from the State of Michigan. Maternal plasma was collected in the first and third trimesters of gestation, as well as umbilical cord blood, with the aim of studying metabolic changes throughout pregnancy and influences on the infant's metabolome. The data is split into two experiment subsets, assayed with different H2O-methanol gradients and mass spectrometers 2-3 years apart, inducing major chromatographic and signal measurement shifts. Analysis steps consisted of disparate LC-MS alignment and data normalization, followed by differential timepoint comparisons and partial correlation network construction. |
| Institute | University of Michigan |
| Department | Computational Medicine and Bioinformatics |
| Last Name | Habra |
| First Name | Hani |
| Address | 100 Washtenaw Ave., Palmer Commons Bldg. Ann Arbor, MI 48109-2218 |
| hhani@umich.edu | |
| Phone | 734-615-9314 |
| Submit Date | 2022-04-13 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d, wiff |
| Analysis Type Detail | LC-MS |
| Release Date | 2022-05-02 |
| Release Version | 1 |
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Project:
| Project ID: | PR001352 |
| Project DOI: | doi: 10.21228/M8ZD7C |
| Project Title: | Influence of prenatal exposures to metals, BPA, and phthalates on mother and child metabolite and lipid profiles |
| Project Summary: | The goal of the project is to examine relationships between prenatal exposures (to metals, BPA, and phthalates) and metabolite and lipid profiles using untargeted approaches in mother-infant pairs from the Michigan Mother Infant Pairs (MMIP) cohort. We are interested in differences/correlations between family samples over time, and the extent to which maternal exposures impact the lipidomes and metabolomes of both family members. Three plasma samples were analyzed from each family: two maternal samples (from first trimester and time of admission for labor and delivery) and one child sample (from cord blood). Placentas were also collected. Mothers provided detailed demographic information and clinical phenotypes were obtained, including mid-gestation fetal ultrasound. |
| Institute: | University of Michigan |
| Department: | Biomedical Research Core Facilities |
| Laboratory: | Metabolomics core |
| Last Name: | Kachman |
| First Name: | Maureen |
| Address: | 2900 Huron Parkway, Ann Arbor, MI, 48105, USA |
| Email: | mkachman@med.umich.edu |
| Phone: | 734-232-0842 |
