Summary of Study ST000017

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000016. The data can be accessed directly via it's Project DOI: 10.21228/M86P45 This work is supported by NIH grant, U2C- DK119886.


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Study IDST000017
Study TitleRat HCR/LCR Stamina Study
Study TypeLC-MS analysis (Untargeted)
Study SummaryMaximal exercise-associated oxidative capacity is strongly correlated with health and longevity in humans. Rats selectively bred for high running capacity (HCR) have improved metabolic health and are longer-lived than their low-capacity counterparts (LCR). Using metabolomic and proteomic profiling, we show that HCR efficiently oxidize fatty acids (FAs) and branched-chain amino acids (BCAAs), sparing glycogen and reducing accumulation of short- and medium-chain acylcarnitines. HCR mitochondria have reduced acetylation of mitochondrial proteins within oxidative pathways at rest, and there is rapid protein deacetylation with exercise, which is greater in HCR than LCR. Fluxomic analysis of valine degradation with exercise demonstrates a functional role of differential protein acetylation in HCR and LCR. Our data suggest that efficient FA and BCAA utilization contribute to high intrinsic exercise capacity and the health and longevity benefits associated with enhanced fitness. Research is published, untargeted data not used in publication but project description is relevant:
University of Michigan
DepartmentInternal Medicine
LaboratoryBurant Lab (MMOC)
Last NameQi
First NameNathan
Submit Date2013-09-24
Num Groups2
Total Subjects42
Raw Data AvailableYes
Uploaded File Size6.8 M
Analysis Type DetailLC-MS
Release Date2013-10-24
Release Version1
Nathan Qi Nathan Qi application/zip

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Subject ID:SU000033
Subject Type:Animal
Subject Species:Rattus norvegicus
Taxonomy ID:10116
Genotype Strain:Low Capacity Running | High Capacity Running
Species Group:Mammal