Summary of Study ST001665
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001070. The data can be accessed directly via it's Project DOI: 10.21228/M8D12Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001665 |
| Study Title | Branched-chain alpha-ketoacids are preferentially reaminated and activate protein synthesis in the rat heart |
| Study Summary | Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that the major metabolic fate of uniformly-13C-labeled α-ketoisovalerate ([U-13C]KIV) in the heart is reamination to valine. Activation of cardiac branched-chain α-ketoacid dehydrogenase (BCKDH) by treatment with the BCKDH kinase inhibitor, BT2, does not impede the strong flux of [U-13C]KIV to valine. |
| Institute | Duke University |
| Last Name | Walejko |
| First Name | Jacquelyn |
| Address | 300 N Duke St |
| jacquelyn.walejko@duke.edu | |
| Phone | 9194792304 |
| Submit Date | 2021-01-26 |
| Analysis Type Detail | GC-MS |
| Release Date | 2021-02-17 |
| Release Version | 1 |
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Subject:
| Subject ID: | SU001742 |
| Subject Type: | Mammal |
| Subject Species: | Rattus norvegicus |
| Taxonomy ID: | 10116 |
| Age Or Age Range: | 10 weeks |
| Gender: | Male |
