Summary of Study ST002249
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001437. The data can be accessed directly via it's Project DOI: 10.21228/M8ZX31 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002249 |
| Study Title | Sex-dependent effects of FGF21 on hepatic metabolism |
| Study Summary | To investigate sex-dependent effects of fibroblast growth factor-21 (FGF21), diet-induced obese male and female wildtype mice were administered two acute doses of FGF21 or saline vehicle. Mice were euthanized, livers collected, and submitted for untargeted metabolomics analysis. |
| Institute | University of California, Davis |
| Department | Neurobiology, Physiology and Behavior |
| Laboratory | Ryan |
| Last Name | Chaffin |
| First Name | Aki |
| Address | 1 Shields Ave |
| atchaffin@ucdavis.edu | |
| Phone | 603-359-1907 |
| Submit Date | 2022-08-09 |
| Num Groups | 4 |
| Total Subjects | 41 |
| Num Males | 22 |
| Num Females | 19 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | cdf |
| Analysis Type Detail | GC-MS |
| Release Date | 2022-08-22 |
| Release Version | 1 |
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Treatment:
| Treatment ID: | TR002347 |
| Treatment Summary: | Male and female C57BL/6J mice were placed on 60% high-fat diet (Research Diets, Cat# D12492) for approx. 10 weeks beginning at 10 weeks of age. Mice were then counterbalanced into two treatment groups based on body weight (n = 9-11 mice/ sex/ treatment). For experiment, one dose of FGF21 (0.1 mg/kg, ip) or saline vehicle was given right before the onset of the dark cycle, then another dose (0.1 mg/kg, ip) was given the following morning after the onset of the light cycle. Mice were euthanized two hours following the AM injection, livers collected, and frozen in liquid N2. |
| Treatment Compound: | recombinant human FGF21 (ProSpecBio, Cat# CYT-474) |
| Treatment Route: | intraperitoneal injection |
| Treatment Dose: | 0.1 mg/kg |
| Treatment Dosevolume: | 0.01 mg/mL |
| Treatment Vehicle: | saline |
