Summary of Study ST000770

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000556. The data can be accessed directly via it's Project DOI: 10.21228/M8ST09 This work is supported by NIH grant, U2C- DK119886.

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Study IDST000770
Study TitleIntranasal oxytocin in lean and obese men
Study TypeMS analysis
Study SummaryFrom Lawson et al., Obesity 2015 (PMID: 25865294). Methods: A randomized, placebo-controlled crossover study of single-dose intranasal oxytocin (24 IU) in 25 fasting healthy men was performed. After oxytocin/placebo, subjects selected breakfast from a menu and were given double portions. Caloric content of food consumed was measured. Visual analog scales were used to assess appetite, and blood was drawn for appetite-regulating hormones, insulin, and glucose before and after oxytocin/placebo. Indirect calorimetry assessed resting energy expenditure (REE) and substrate utilization. Here, T0 refers to immediately before OXT or Placebo was administered (fasting), and T55 refers to 55 minutes post-administration (fasting, immediately pre-meal).
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2017-06-19
Num Groups8
Total Subjects25
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8ST09
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000556
Project DOI:doi: 10.21228/M8ST09
Project Title:Effects of OXT on fatty acid oxidation
Project Type:MS analysis
Project Summary:Test the effects of OXT on fatty acid oxidation
Institute:Children's Hospital of Philadelphia
Department:Division of Endocrinology and Diabetes
Laboratory:McCormack Lab
Last Name:McCormack
First Name:Shana
Address:Philadelphia, PA
Email:mccormacks1@email.chop.edu
Phone:617-596-9067

Subject:

Subject ID:SU000793
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Mammals

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Adiposity Condition Timepoint Visit
SA042091S00024515Lean Oxytocin T0 MV1
SA042092S00024519Lean Oxytocin T0 MV1
SA042093S00024507Lean Oxytocin T0 MV1
SA042094S00024499Lean Oxytocin T0 MV1
SA042095S00024491Lean Oxytocin T0 MV1
SA042096S00024495Lean Oxytocin T0 MV1
SA042097S00024511Lean Oxytocin T0 MV1
SA042098S00024523Lean Oxytocin T0 MV1
SA042099S00024471Lean Oxytocin T0 MV1
SA042100S00024479Lean Oxytocin T0 MV1
SA042101S00024503Lean Oxytocin T0 MV1
SA042102S00024527Lean Oxytocin T0 MV1
SA042103S00024475Lean Oxytocin T0 MV1
SA042104S00024512Lean Oxytocin T55 MV1
SA042105S00024492Lean Oxytocin T55 MV1
SA042106S00024496Lean Oxytocin T55 MV1
SA042107S00024508Lean Oxytocin T55 MV1
SA042108S00024500Lean Oxytocin T55 MV1
SA042109S00024472Lean Oxytocin T55 MV1
SA042110S00024528Lean Oxytocin T55 MV1
SA042111S00024480Lean Oxytocin T55 MV1
SA042112S00024524Lean Oxytocin T55 MV1
SA042113S00024520Lean Oxytocin T55 MV1
SA042114S00024504Lean Oxytocin T55 MV1
SA042115S00024476Lean Oxytocin T55 MV1
SA042116S00024516Lean Oxytocin T55 MV1
SA042117S00024505Lean Placebo T0 MV2
SA042118S00024517Lean Placebo T0 MV2
SA042119S00024529Lean Placebo T0 MV2
SA042120S00024525Lean Placebo T0 MV2
SA042121S00024513Lean Placebo T0 MV2
SA042122S00024509Lean Placebo T0 MV2
SA042123S00024521Lean Placebo T0 MV2
SA042124S00024493Lean Placebo T0 MV2
SA042125S00024473Lean Placebo T0 MV2
SA042126S00024481Lean Placebo T0 MV2
SA042127S00024497Lean Placebo T0 MV2
SA042128S00024477Lean Placebo T0 MV2
SA042129S00024501Lean Placebo T0 MV2
SA042130S00024526Lean Placebo T55 MV2
SA042131S00024506Lean Placebo T55 MV2
SA042132S00024482Lean Placebo T55 MV2
SA042133S00024478Lean Placebo T55 MV2
SA042134S00024474Lean Placebo T55 MV2
SA042135S00024502Lean Placebo T55 MV2
SA042136S00024510Lean Placebo T55 MV2
SA042137S00024522Lean Placebo T55 MV2
SA042138S00024530Lean Placebo T55 MV2
SA042139S00024518Lean Placebo T55 MV2
SA042140S00024494Lean Placebo T55 MV2
SA042141S00024514Lean Placebo T55 MV2
SA042142S00024498Lean Placebo T55 MV2
SA042143S00024559Obese Oxytocin T0 MV1
SA042144S00024539Obese Oxytocin T0 MV1
SA042145S00024555Obese Oxytocin T0 MV1
SA042146S00024551Obese Oxytocin T0 MV1
SA042147S00024547Obese Oxytocin T0 MV1
SA042148S00024567Obese Oxytocin T0 MV1
SA042149S00024563Obese Oxytocin T0 MV1
SA042150S00024543Obese Oxytocin T0 MV1
SA042151S00024535Obese Oxytocin T0 MV1
SA042152S00024487Obese Oxytocin T0 MV1
SA042153S00024483Obese Oxytocin T0 MV1
SA042154S00024531Obese Oxytocin T0 MV1
SA042155S00024488Obese Oxytocin T55 MV1
SA042156S00024544Obese Oxytocin T55 MV1
SA042157S00024560Obese Oxytocin T55 MV1
SA042158S00024484Obese Oxytocin T55 MV1
SA042159S00024548Obese Oxytocin T55 MV1
SA042160S00024532Obese Oxytocin T55 MV1
SA042161S00024568Obese Oxytocin T55 MV1
SA042162S00024556Obese Oxytocin T55 MV1
SA042163S00024536Obese Oxytocin T55 MV1
SA042164S00024552Obese Oxytocin T55 MV1
SA042165S00024564Obese Oxytocin T55 MV1
SA042166S00024540Obese Oxytocin T55 MV1
SA042167S00024553Obese Placebo T0 MV2
SA042168S00024557Obese Placebo T0 MV2
SA042169S00024561Obese Placebo T0 MV2
SA042170S00024565Obese Placebo T0 MV2
SA042171S00024533Obese Placebo T0 MV2
SA042172S00024485Obese Placebo T0 MV2
SA042173S00024489Obese Placebo T0 MV2
SA042174S00024569Obese Placebo T0 MV2
SA042175S00024537Obese Placebo T0 MV2
SA042176S00024549Obese Placebo T0 MV2
SA042177S00024545Obese Placebo T0 MV2
SA042178S00024541Obese Placebo T0 MV2
SA042179S00024570Obese Placebo T55 MV2
SA042180S00024566Obese Placebo T55 MV2
SA042181S00024538Obese Placebo T55 MV2
SA042182S00024534Obese Placebo T55 MV2
SA042183S00024486Obese Placebo T55 MV2
SA042184S00024490Obese Placebo T55 MV2
SA042185S00024542Obese Placebo T55 MV2
SA042186S00024546Obese Placebo T55 MV2
SA042187S00024558Obese Placebo T55 MV2
SA042188S00024554Obese Placebo T55 MV2
SA042189S00024550Obese Placebo T55 MV2
SA042190S00024562Obese Placebo T55 MV2
Showing results 1 to 100 of 100

Collection:

Collection ID:CO000787
Collection Summary:-
Sample Type:Blood

Treatment:

Treatment ID:TR000807
Treatment Summary:-

Sample Preparation:

Sampleprep ID:SP000800
Sampleprep Summary:-
Sampleprep Protocol Filename:A008_-_Acyl_Carnitines.pdf

Chromatography:

Chromatography ID:CH000853
Instrument Name:Agilent
Column Name:Waters Xbridge BEH C18 (50 x 1mm,3.5um)
Column Temperature:40
Flow Rate:0.250 mL/min
Solvent A:100% water; 5 mM ammonium acetate, pH 9.9
Solvent B:100% acetonitrile
Chromatography Type:Reversed phase

Analysis:

Analysis ID:AN001217
Analysis Type:MS
Analysis Protocol File:A008_-_Acyl_Carnitines.pdf
Instrument Name:6490A QQQ LC/MS (Agilent)
Chromatography ID:CH000853
Num Factors:8
Num Metabolites:30
Units:uM
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