Summary of Study ST001746

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001113. The data can be accessed directly via it's Project DOI: 10.21228/M8TX2D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001746
Study TitleExamining the Identified Differential Metabolites in Other Antipsychotics with a High Fatality Frequency
Study SummaryExamining the Identified Differential Metabolites in Other Antipsychotics with a High Fatality Frequency
Institute
Hebei medical university
Last Namerui
First Namebai
Addresschina
Email15822925144@163.com
Phone18522889554
Submit Date2021-03-30
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2025-03-30
Release Version1
bai rui bai rui
https://dx.doi.org/10.21228/M8TX2D
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR001113
Project DOI:doi: 10.21228/M8TX2D
Project Title:Examination of Candidate Differential Metabolites for Lethal Chlorpromazine Poisoning Using a LC-MS-based Metabolomics Approach in Mice
Project Type:Original Research
Project Summary:With the innovation of metabolite detection technology and the application of chemometrics in biomarker identification, metabolomics has been widely used to identify endogenous differential metabolites after drug poisoning. In this study, ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) was combined with advanced chemometric approaches to identify differential metabolites that are associated with lethal chlorpromazine (CPZ) poisoning and associated perturbed metabolic pathways. Differential metabolite specificity and stability were assessed by comparing the CPZ samples to other antipsychotics, such as perphenazine (PER), clozapine (CLO) and olanzapine (OLA), that are associated with a high fatality frequency and by comparing them to non-drug related deaths (NDRDs) associated with hypoxia. The results implicated three candidate differential metabolites (acetyl-L-carnitine, propionyl-L-carnitine and succinic acid) with a high and relatively stable sensitivity (85.7–100%) following predictive analysis. Additionally, no differential metabolites were identified when comparing CPZ to PRE, OLA and CLO, but all of the drugs showed a similar pharmacodynamic receptor profile. Overall, this study provides a methodological and theoretical basis for biomarker identification in lethal CPZ poisoning (LCP) cases.
Institute:new
Last Name:Bai
First Name:rui
Address:Hebei Province, Shijiazhuang 050018, P.R. China
Email:15822925144@163.com
Phone:18522889554

Subject:

Subject ID:SU001823
Subject Type:Mammal
Subject Species:Mus musculus
Taxonomy ID:10090
Species Group:Mammals

Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Phenotype 1 Phenotype 2 Phenotype 3
SA163353FT4Cervical dislocation Non-drug related death Non-drug related death
SA163354FT3Cervical dislocation Non-drug related death Non-drug related death
SA163355FT2Cervical dislocation Non-drug related death Non-drug related death
SA163356MT1Cervical dislocation Non-drug related death Non-drug related death
SA163357MT3Cervical dislocation Non-drug related death Non-drug related death
SA163358MT5Cervical dislocation Non-drug related death Non-drug related death
SA163359MT4Cervical dislocation Non-drug related death Non-drug related death
SA163360FT1Cervical dislocation Non-drug related death Non-drug related death
SA163361MT2Cervical dislocation Non-drug related death Non-drug related death
SA163362FT5Cervical dislocation Non-drug related death Non-drug related death
SA163363FN5Drowning Non-drug related death Non-drug related death
SA163364FN4Drowning Non-drug related death Non-drug related death
SA163365FN3Drowning Non-drug related death Non-drug related death
SA163366MN1Drowning Non-drug related death Non-drug related death
SA163367MN2Drowning Non-drug related death Non-drug related death
SA163368MN5Drowning Non-drug related death Non-drug related death
SA163369MN4Drowning Non-drug related death Non-drug related death
SA163370MN3Drowning Non-drug related death Non-drug related death
SA163371FN2Drowning Non-drug related death Non-drug related death
SA163372FN1Drowning Non-drug related death Non-drug related death
SA163373FX1Hemorrhagic shock Non-drug related death Non-drug related death
SA163374FX4Hemorrhagic shock Non-drug related death Non-drug related death
SA163375FX3Hemorrhagic shock Non-drug related death Non-drug related death
SA163376FX5Hemorrhagic shock Non-drug related death Non-drug related death
SA163377MX2Hemorrhagic shock Non-drug related death Non-drug related death
SA163378MX5Hemorrhagic shock Non-drug related death Non-drug related death
SA163379MX4Hemorrhagic shock Non-drug related death Non-drug related death
SA163380MX3Hemorrhagic shock Non-drug related death Non-drug related death
SA163381FX2Hemorrhagic shock Non-drug related death Non-drug related death
SA163382MX1Hemorrhagic shock Non-drug related death Non-drug related death
SA163383FLS2Lethal CLO poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163384FLS5Lethal CLO poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163385MLS5Lethal CLO poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163386FLS4Lethal CLO poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163387MLS1Lethal CLO poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163388MLS2Lethal CLO poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163389MLS4Lethal CLO poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163390FLS3Lethal CLO poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163391MLS3Lethal CLO poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163392FLS1Lethal CLO poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163393MCS5Lethal CPZ poisoning Lethal CPZ poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163394FCS1Lethal CPZ poisoning Lethal CPZ poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163395MCS2Lethal CPZ poisoning Lethal CPZ poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163396MCS3Lethal CPZ poisoning Lethal CPZ poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163397MCS4Lethal CPZ poisoning Lethal CPZ poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163398MCS1Lethal CPZ poisoning Lethal CPZ poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163399FCS5Lethal CPZ poisoning Lethal CPZ poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163400FCS3Lethal CPZ poisoning Lethal CPZ poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163401FCS4Lethal CPZ poisoning Lethal CPZ poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163402FCS2Lethal CPZ poisoning Lethal CPZ poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163403MOS2Lethal OLA poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163404MOS4Lethal OLA poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163405MOS5Lethal OLA poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163406FOS2Lethal OLA poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163407MOS3Lethal OLA poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163408MOS1Lethal OLA poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163409FOS3Lethal OLA poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163410FOS4Lethal OLA poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163411FOS5Lethal OLA poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163412FOS1Lethal OLA poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163413FFS1Lethal PER poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163414FFS4Lethal PER poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163415FFS3Lethal PER poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163416FFS2Lethal PER poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163417FFS5Lethal PER poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163418MFS1Lethal PER poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163419MFS4Lethal PER poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163420MFS3Lethal PER poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163421MFS2Lethal PER poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163422MFS5Lethal PER poisoning PER, OLA, CLO lethal poisoning CPZ, PER, OLA, CLO lethal poisoning
SA163423FZ1Mechanical asphyxia Non-drug related death Non-drug related death
SA163424FZ4Mechanical asphyxia Non-drug related death Non-drug related death
SA163425FZ3Mechanical asphyxia Non-drug related death Non-drug related death
SA163426FZ2Mechanical asphyxia Non-drug related death Non-drug related death
SA163427FZ5Mechanical asphyxia Non-drug related death Non-drug related death
SA163428MZ1Mechanical asphyxia Non-drug related death Non-drug related death
SA163429MZ4Mechanical asphyxia Non-drug related death Non-drug related death
SA163430MZ3Mechanical asphyxia Non-drug related death Non-drug related death
SA163431MZ2Mechanical asphyxia Non-drug related death Non-drug related death
SA163432MZ5Mechanical asphyxia Non-drug related death Non-drug related death
Showing results 1 to 80 of 80

Collection:

Collection ID:CO001816
Collection Summary:blood samples were centrifuged at 5,000 g for 5 min and then centrifuged at 8,000 g for 5 min at 4°C to obtain plasma. All plasma samples were then snap-frozen in liquid nitrogen and stored at -80°C. Whole blood samples that were utilized to access stability were immediately stored at -80 °C following collection.
Sample Type:Blood (plasma)

Treatment:

Treatment ID:TR001836
Treatment Summary:blood samples were centrifuged at 5,000 g for 5 min and then centrifuged at 8,000 g for 5 min at 4°C to obtain plasma. All plasma samples were then snap-frozen in liquid nitrogen and stored at -80°C. Whole blood samples that were utilized to access stability were immediately stored at -80 °C following collection.

Sample Preparation:

Sampleprep ID:SP001829
Sampleprep Summary:blood samples were centrifuged at 5,000 g for 5 min and then centrifuged at 8,000 g for 5 min at 4°C to obtain plasma. All plasma samples were then snap-frozen in liquid nitrogen and stored at -80°C. Whole blood samples that were utilized to access stability were immediately stored at -80 °C following collection.

Combined analysis:

Analysis ID AN002842
Chromatography ID CH002103
MS ID MS002635
Analysis type MS
Chromatography type Reversed phase
Chromatography system Thermo Dionex Ultimate 3000
Column Waters Acquity BEH HSS T3 (100 x 2.1mm,1.8um)
MS Type ESI
MS instrument type Orbitrap
MS instrument name Thermo Q Exactive Orbitrap
Ion Mode UNSPECIFIED
Units peak area

Chromatography:

Chromatography ID:CH002103
Chromatography Summary:Low pH polar
Instrument Name:Thermo Dionex Ultimate 3000
Column Name:Waters Acquity BEH HSS T3 (100 x 2.1mm,1.8um)
Chromatography Type:Reversed phase

MS:

MS ID:MS002635
Analysis ID:AN002842
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
MS Comments:Proprietary analytical software for integration and peak picking
Ion Mode:UNSPECIFIED
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