Summary of Study ST002087

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001326. The data can be accessed directly via it's Project DOI: 10.21228/M89T2Q This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002087
Study TitleProfiling metabolites and lipoproteins in COMETA, an Italian cohort of COVID-19 patients
Study TypeNMR-based metabolomics
Study Summary1H NMR spectra of EDTA-plasma from 246 COVID-19-positive subjects in the acute phase of infection were compared to those of 94 COVID-19-recovered subjects. The two cohorts are largely different (discrimination accuracy > 93%) due to a pool of 16 metabolites and 74 lipoprotein parameters significantly up- or down-regulated in the patients and within the healthy range in the recovered subjects. In 28 post-acute COVID-19-positive patients, the metabolites levels are reverted back to normality whereas the lipoprotein parameters are still altered. Therefore, the metabolite biomarkers might be used as the timeliest sign of the individual response to treatment or spontaneous healing.
Institute
University of Florence
DepartmentDepartment of Chemistry
Laboratorymetabolomics
Last NameGhini
First NameVeronica
Addressvia Luigi Sacconi
Emailghini@cerm.unifi.it
Phone+390554574266
Submit Date2022-02-17
Num Groups3
Total Subjects368
Num Males201
Num Females167
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2022-03-16
Release Version1
Veronica Ghini Veronica Ghini
https://dx.doi.org/10.21228/M89T2Q
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR001326
Project DOI:doi: 10.21228/M89T2Q
Project Title:Profiling metabolites and lipoproteins in COMETA, an Italian cohort of COVID-19 patients
Project Type:NMR-based metabolomics
Project Summary:1H NMR spectra of EDTA-plasma from 246 COVID-19-positive subjects in the acute phase of infection were compared to those of 95 COVID-19-recovered subjects. The two cohorts are largely different (discrimination accuracy > 93%) due to a pool of 16 metabolites and 74 lipoprotein parameters significantly up- or down-regulated in the patients and within the healthy range in the recovered subjects. In 28 post-acute COVID-19-positive patients, the metabolites levels are reverted back to normality whereas the lipoprotein parameters are still altered. Therefore, the metabolite biomarkers might be used as the timeliest sign of the individual response to treatment or spontaneous healing.
Institute:University of Florence
Department:Department of Chemistry
Laboratory:Metabolomics
Last Name:Ghini
First Name:Veronica
Address:via Luigi Sacconi 6
Email:ghini@cerm.unifi.it
Phone:+390554574266
Funding Source:COMETA project, funded by the Tuscany Region,Italy

Subject:

Subject ID:SU002171
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Gender:Male and female
Human Inclusion Criteria:hospedalized COVID-19 patients

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Grade of severity Group
SA19847121Asymptomatic COVID-19>21days
SA19847224Asymptomatic COVID-19>21days
SA19847317Asymptomatic COVID-19>21days
SA198474266Asymptomatic COVID-19>21days
SA19847599Asymptomatic COVID-19>21days
SA19847610Asymptomatic COVID-19>21days
SA19847715Asymptomatic COVID-19>21days
SA19847812Asymptomatic COVID-19>21days
SA19847913Asymptomatic COVID-19>21days
SA198436361Asymptomatic COVID-19<21days
SA198437365Asymptomatic COVID-19<21days
SA198438399Asymptomatic COVID-19<21days
SA198439360Asymptomatic COVID-19<21days
SA198440358Asymptomatic COVID-19<21days
SA198441347Asymptomatic COVID-19<21days
SA198442350Asymptomatic COVID-19<21days
SA198443408Asymptomatic COVID-19<21days
SA198444476Asymptomatic COVID-19<21days
SA198445485Asymptomatic COVID-19<21days
SA198446491Asymptomatic COVID-19<21days
SA1984476Asymptomatic COVID-19<21days
SA198448483Asymptomatic COVID-19<21days
SA198449482Asymptomatic COVID-19<21days
SA198450335Asymptomatic COVID-19<21days
SA198451479Asymptomatic COVID-19<21days
SA198452475Asymptomatic COVID-19<21days
SA198453338Asymptomatic COVID-19<21days
SA198454111Asymptomatic COVID-19<21days
SA198455112Asymptomatic COVID-19<21days
SA198456113Asymptomatic COVID-19<21days
SA19845720Asymptomatic COVID-19<21days
SA19845819Asymptomatic COVID-19<21days
SA1984597Asymptomatic COVID-19<21days
SA1984609Asymptomatic COVID-19<21days
SA198461205Asymptomatic COVID-19<21days
SA198462133Asymptomatic COVID-19<21days
SA198463283Asymptomatic COVID-19<21days
SA198464324Asymptomatic COVID-19<21days
SA198465333Asymptomatic COVID-19<21days
SA198466223Asymptomatic COVID-19<21days
SA198467263Asymptomatic COVID-19<21days
SA198468254Asymptomatic COVID-19<21days
SA198469231Asymptomatic COVID-19<21days
SA198470245Asymptomatic COVID-19<21days
SA19848027Asymptomatic Post-COVID-19
SA19848150Asymptomatic Post-COVID-20
SA19848266Asymptomatic Post-COVID-21
SA19848384Asymptomatic Post-COVID-22
SA19848490Asymptomatic Post-COVID-23
SA198485123Asymptomatic Post-COVID-24
SA198486185Asymptomatic Post-COVID-26
SA198487186Asymptomatic Post-COVID-27
SA198488187Asymptomatic Post-COVID-28
SA198489192Asymptomatic Post-COVID-29
SA198490346Asymptomatic Post-COVID-30
SA198491382Asymptomatic Post-COVID-31
SA19857622Mild COVID-19>21days
SA19857725Mild COVID-19>21days
SA19857818Mild COVID-19>21days
SA19857914Mild COVID-19>21days
SA19858041Mild COVID-19>21days
SA19858163Mild COVID-19>21days
SA19858297Mild COVID-19>21days
SA19858364Mild COVID-19>21days
SA198584395Mild COVID-19>21days
SA19858596Mild COVID-19>21days
SA198492416Mild COVID-19<21days
SA198493415Mild COVID-19<21days
SA198494421Mild COVID-19<21days
SA198495422Mild COVID-19<21days
SA198496433Mild COVID-19<21days
SA198497426Mild COVID-19<21days
SA198498412Mild COVID-19<21days
SA198499410Mild COVID-19<21days
SA198500398Mild COVID-19<21days
SA198501394Mild COVID-19<21days
SA198502402Mild COVID-19<21days
SA198503405Mild COVID-19<21days
SA198504393Mild COVID-19<21days
SA198505407Mild COVID-19<21days
SA198506435Mild COVID-19<21days
SA198507464Mild COVID-19<21days
SA198508468Mild COVID-19<21days
SA198509467Mild COVID-19<21days
SA198510469Mild COVID-19<21days
SA198511473Mild COVID-19<21days
SA198512391Mild COVID-19<21days
SA198513480Mild COVID-19<21days
SA198514461Mild COVID-19<21days
SA198515454Mild COVID-19<21days
SA198516440Mild COVID-19<21days
SA198517439Mild COVID-19<21days
SA198518441Mild COVID-19<21days
SA198519448Mild COVID-19<21days
SA198520453Mild COVID-19<21days
SA198521438Mild COVID-19<21days
SA198522428Mild COVID-19<21days
SA198523234Mild COVID-19<21days
SA198524239Mild COVID-19<21days
SA198525232Mild COVID-19<21days
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Collection:

Collection ID:CO002164
Collection Summary:The analysed were done on EDTA-plasma. All the samples were collected, processed and stored following the ISO standards (ISO 23118:2021), designed for high quality biological samples for metabolomic analysis
Sample Type:Blood (plasma)
Storage Conditions:-80℃

Treatment:

Treatment ID:TR002183
Treatment Summary:not applicable

Sample Preparation:

Sampleprep ID:SP002177
Sampleprep Summary:Frozen EDTA-plasma samples were thawed at room temperature and shaken before use. A total of 350 μL of sodium phosphate buffer (70 mM Na2HPO4; 20% (v/v) 2H2O; 6.1 mM NaN3, 4.6 mM sodium trimethylsilyl [2,2,3,3−2H4] propionate (TMSP), pH 7.4) was added to 350 μL of each serum sample; the mixture was homogenized by vortexing for 30 s. A total of 600 μL of each mixture was transferred into a 5.00 mm NMR tube (Bruker BioSpin) for the analysis.

Analysis:

Analysis ID:AN003405
Laboratory Name:Metabolomics
Analysis Type:NMR
Num Factors:102
Num Metabolites:139
Units:uM

NMR:

NMR ID:NM000231
Analysis ID:AN003405
Instrument Name:Bruker 600MHZ
Instrument Type:FT-NMR
NMR Experiment Type:1D-1H
Spectrometer Frequency:600 MHz
NMR Probe:5 mm PATXI 1H−13C−15N and 2H-decoupling probe
NMR Tube Size:5 mm
Pulse Sequence:noesygp1d
Water Suppression:water peak suppression
Dummy Scans:4
Acquisition Time:2.7 s
Relaxation Delay:4 s
Spectral Width:18,028 Hz
Num Data Points Acquired:98000
Line Broadening:0.3
Baseline Correction Method:automatic baseline correction
Chemical Shift Ref Std:doublet at 5.24 ppm
Binned Increment:0.2 ppm
Binned Data Excluded Range:4.5-5.5 ppm
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