MGP Database

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MGP000001

Ontology/Pathway Information

Entrez Gene ID2
Gene Namealpha-2-macroglobulin
Gene Symbol A2M
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0072562 IDA:UniProtKBCblood microparticle
GO:0005829 TAS:ReactomeCcytosol
GO:0005576 NAS:UniProtKBCextracellular region
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0048306 IPI:AgBaseFcalcium-dependent protein binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0019838 IDA:UniProtKBFgrowth factor binding
GO:0019966 IDA:UniProtKBFinterleukin-1 binding
GO:0019959 IPI:UniProtKBFinterleukin-8 binding
GO:0002020 IPI:BHF-UCLFprotease binding
GO:0005102 IMP:AgBaseFreceptor binding
GO:0004867 IDA:UniProtKBFserine-type endopeptidase inhibitor activity
GO:0043120 IDA:UniProtKBFtumor necrosis factor binding
GO:0007596 TAS:ReactomePblood coagulation
GO:0007597 TAS:ReactomePblood coagulation, intrinsic pathway
GO:0022617 TAS:ReactomePextracellular matrix disassembly
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0001869 IDA:UniProtKBPnegative regulation of complement activation, lectin pathway
GO:0010951 IDA:GOCPnegative regulation of endopeptidase activity
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0051056 TAS:ReactomePregulation of small GTPase mediated signal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0048863 IEA:EnsemblPstem cell differentiation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118572Degradation of the extracellular matrix
REACT_118779Extracellular matrix organization
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_13621HDL-mediated lipid transport
REACT_604Hemostasis
REACT_326Intrinsic Pathway
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_11051Rho GTPase cycle
REACT_11044Signaling by Rho GTPases
REACT_111102Signal Transduction
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