MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000002

Record overview

MGPD IDMGP000002
Gene ID9
SpeciesHomo sapiens (Human)
Gene NameN-acetyltransferase 1 (arylamine N-acetyltransferase)
Gene Symbol NAT1
SynonymsAAC1; MNAT; NATI; NAT-1;
Alternate namesarylamine N-acetyltransferase 1; arylamide acetylase 1; N-acetyltransferase type 1; monomorphic arylamine N-acetyltransferase;
Chromosome8
Map Location8p22
EC Number2.3.1.5
SummaryThis gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for NAT1

Proteins

arylamine N-acetyltransferase 1 isoform a
Refseq ID:NP_001153651
Protein GI:237649009
UniProt ID:P18440
mRNA ID:NM_001160179
Length:290
RefSeq Status:
MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVVRRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKK
YSTGMIHLLLQVTIDGRNYIVDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDLLEDSKYRKIYSFTLKPRTIE
DFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLTHRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI
 
arylamine N-acetyltransferase 1 isoform a
Refseq ID:NP_000653
Protein GI:42741671
UniProt ID:P18440
mRNA ID:NM_000662
Length:290
RefSeq Status:
Protein sequence is identical to GI:237649009 (mRNA isoform)
 
arylamine N-acetyltransferase 1 isoform a
Refseq ID:NP_001153645
Protein GI:237649126
UniProt ID:P18440
mRNA ID:NM_001160173
Length:290
RefSeq Status:
Protein sequence is identical to GI:237649009 (mRNA isoform)
 
arylamine N-acetyltransferase 1 isoform a
Refseq ID:NP_001153644
Protein GI:237649124
UniProt ID:P18440
mRNA ID:NM_001160172
Length:290
RefSeq Status:
Protein sequence is identical to GI:237649009 (mRNA isoform)
 
arylamine N-acetyltransferase 1 isoform a
Refseq ID:NP_001153643
Protein GI:237649122
UniProt ID:P18440
mRNA ID:NM_001160171
Length:290
RefSeq Status:
Protein sequence is identical to GI:237649009 (mRNA isoform)
 
arylamine N-acetyltransferase 1 isoform a
Refseq ID:NP_001153642
Protein GI:237649119
UniProt ID:P18440
mRNA ID:NM_001160170
Length:290
RefSeq Status:
Protein sequence is identical to GI:237649009 (mRNA isoform)
 
arylamine N-acetyltransferase 1 isoform a
Refseq ID:NP_001153646
Protein GI:237649128
UniProt ID:P18440
mRNA ID:NM_001160174
Length:290
RefSeq Status:
Protein sequence is identical to GI:237649009 (mRNA isoform)
 
arylamine N-acetyltransferase 1 isoform b
Refseq ID:NP_001153647
Protein GI:237649130
UniProt ID:Q400J6
mRNA ID:NM_001160175
Length:352
RefSeq Status:
MLLLLLHKEAALEPQGPAVGYNSLPVSDDHHVSGIQARKKQQSVFWIKTEDQPTFNLLRKGIMDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFE
NLNIHCGDAMDLGLEAIFDQVVRRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYIVDAGFGRSYQMWQPLELI
SGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDLLEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFT
LTHRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI
 
arylamine N-acetyltransferase 1 isoform b
Refseq ID:NP_001153648
Protein GI:237649132
UniProt ID:F5H5R8
mRNA ID:NM_001160176
Length:352
RefSeq Status:
Protein sequence is identical to GI:237649130 (mRNA isoform)
 
arylamine N-acetyltransferase 1 isoform b
Refseq ID:NP_001278891
Protein GI:634743286
UniProt ID:F5H5R8
mRNA ID:NM_001291962
Length:352
RefSeq Status:
Protein sequence is identical to GI:237649130 (mRNA isoform)
 
  logo