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MGP000003

UniProt Annotations

Entry Information
Gene NameN-acetyltransferase 2 (arylamine N-acetyltransferase)
Protein EntryARY2_HUMAN
UniProt IDP11245
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + an arylamine = CoA + an N- acetylarylamine.
FunctionParticipates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
PolymorphismPolymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIM:243400] and influence drug therapy response and susceptibility to chemical toxicity or carcinogenicity.
Sequence CautionSequence=AAK51711.1; Type=Frameshift; Positions=287; Evidence={ECO:0000305};
SimilarityBelongs to the arylamine N-acetyltransferase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NAT2ID41498ch8p22.html";
Web ResourceName=NAT; Note=NAT alleles; URL="http://www.louisville.edu/medschool/pharmacology/NAT.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/nat2/";
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=NAT2";
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