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MGP000004

Record overview

MGPD IDMGP000004
Gene ID15
SpeciesHomo sapiens (Human)
Gene Namearalkylamine N-acetyltransferase
Gene Symbol AANAT
SynonymsDSPS; SNAT;
Alternate namesserotonin N-acetyltransferase; serotonin acetylase; arylalkylamine N-acetyltransferase;
Chromosome17
Map Location17q25.1
EC Number2.3.1.87
SummaryThe protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
OrthologsView orthologs and multiple alignments for AANAT

Proteins

serotonin N-acetyltransferase isoform 1
Refseq ID:NP_001160051
Protein GI:262231744
UniProt ID:Q16613
mRNA ID:NM_001166579
Length:252
RefSeq Status:
MEPQSMKGQKRPFGGPWRLKVLGGPPWLRRTLPKLGRPKEAPVARMSTQSTHPLKPEAPRLPPGIPESPSCQRRHTLPASEFRCLTPEDAVSAFEIEREA
FISVLGVCPLYLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKERLMQESLTLHRSGGHIAHLHVLAVHRAFRQQGRGPILLWRYLHHLGSQPAVRR
AALMCEDALVPFYERFSFHAVGPCAITVGSLTFMELHCSLRGHPFLRRNSGC
 
serotonin N-acetyltransferase isoform 2
Refseq ID:NP_001079
Protein GI:4501845
UniProt ID:Q16613
mRNA ID:NM_001088
Length:207
RefSeq Status:
MSTQSTHPLKPEAPRLPPGIPESPSCQRRHTLPASEFRCLTPEDAVSAFEIEREAFISVLGVCPLYLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWD
KERLMQESLTLHRSGGHIAHLHVLAVHRAFRQQGRGPILLWRYLHHLGSQPAVRRAALMCEDALVPFYERFSFHAVGPCAITVGSLTFMELHCSLRGHPF
LRRNSGC
 
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