MGP Database

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MGP000011

Ontology/Pathway Information

Entrez Gene ID25
Gene NameABL proto-oncogene 1, non-receptor tyrosine kinase
Gene Symbol ABL1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0015629 TAS:UniProtKBCactin cytoskeleton
GO:0031252 IEA:EnsemblCcell leading edge
GO:0005737 TAS:UniProtKBCcytoplasm
GO:0005829 IDA:MGICcytosol
GO:0031234 IBA:GO_CentralCextrinsic component of cytoplasmic side of plasma membrane
GO:0005739 NAS:ParkinsonsUK-UCLCmitochondrion
GO:0031965 IEA:UniProtKB-SubCellCnuclear membrane
GO:0005730 IDA:MGICnucleolus
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0003785 TAS:UniProtKBFactin monomer binding
GO:0005524 IDA:UniProtKBFATP binding
GO:0003677 NAS:UniProtKBFDNA binding
GO:0000287 IDA:UniProtKBFmagnesium ion binding
GO:0030145 IDA:UniProtKBFmanganese ion binding
GO:0051019 IPI:BHF-UCLFmitogen-activated protein kinase binding
GO:0004515 TAS:UniProtKBFnicotinate-nucleotide adenylyltransferase activity
GO:0004715 IDA:UniProtKBFnon-membrane spanning protein tyrosine kinase activity
GO:0070064 IDA:UniProtKBFproline-rich region binding
GO:0008022 IPI:UniProtKBFprotein C-terminus binding
GO:0004672 IDA:MGIFprotein kinase activity
GO:0004713 IDA:UniProtKBFprotein tyrosine kinase activity
GO:0005102 IBA:GO_CentralFreceptor binding
GO:0017124 IPI:UniProtKBFSH3 domain binding
GO:0019905 IPI:UniProtKBFsyntaxin binding
GO:0030036 ISS:UniProtKBPactin cytoskeleton organization
GO:0006914 IEA:UniProtKB-KWPautophagy
GO:0007411 TAS:ReactomePaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0007155 IEA:UniProtKB-KWPcell adhesion
GO:0007050 TAS:ParkinsonsUK-UCLPcell cycle arrest
GO:0030154 IBA:GO_CentralPcell differentiation
GO:0016477 IBA:GO_CentralPcell migration
GO:0006464 NAS:UniProtKBPcellular protein modification process
GO:0006974 IDA:UniProtKBPcellular response to DNA damage stimulus
GO:1903351 TAS:ParkinsonsUK-UCLPcellular response to dopamine
GO:0034599 TAS:ParkinsonsUK-UCLPcellular response to oxidative stress
GO:0006975 IDA:UniProtKBPDNA damage induced protein phosphorylation
GO:0007173 IBA:GO_CentralPepidermal growth factor receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 IBA:GO_CentralPinnate immune response
GO:0008630 TAS:UniProtKBPintrinsic apoptotic signaling pathway in response to DNA damage
GO:0006298 TAS:ProtIncPmismatch repair
GO:0051882 TAS:ParkinsonsUK-UCLPmitochondrial depolarization
GO:0007067 TAS:ParkinsonsUK-UCLPmitotic nuclear division
GO:0042692 TAS:ReactomePmuscle cell differentiation
GO:1900275 IMP:MGIPnegative regulation of phospholipase C activity
GO:0071901 IDA:BHF-UCLPnegative regulation of protein serine/threonine kinase activity
GO:0051444 TAS:ParkinsonsUK-UCLPnegative regulation of ubiquitin-protein transferase activity
GO:0038083 IBA:GO_CentralPpeptidyl-tyrosine autophosphorylation
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0048008 IBA:GO_CentralPplatelet-derived growth factor receptor signaling pathway
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0007204 IMP:MGIPpositive regulation of cytosolic calcium ion concentration
GO:0051149 TAS:ReactomePpositive regulation of muscle cell differentiation
GO:0051353 IDA:BHF-UCLPpositive regulation of oxidoreductase activity
GO:0050731 IDA:UniProtKBPpositive regulation of peptidyl-tyrosine phosphorylation
GO:2000249 TAS:UniProtKBPregulation of actin cytoskeleton reorganization
GO:0010506 TAS:UniProtKBPregulation of autophagy
GO:0030155 TAS:UniProtKBPregulation of cell adhesion
GO:2000145 TAS:UniProtKBPregulation of cell motility
GO:0042127 IBA:GO_CentralPregulation of cell proliferation
GO:0030100 TAS:UniProtKBPregulation of endocytosis
GO:2001020 IDA:UniProtKBPregulation of response to DNA damage stimulus
GO:0006355 TAS:ProtIncPregulation of transcription, DNA-templated
GO:0006979 IGI:MGIPresponse to oxidative stress
GO:0042770 IDA:UniProtKBPsignal transduction in response to DNA damage
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18266Axon guidance
REACT_21402CDO in myogenesis
REACT_111045Developmental Biology
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_21303Myogenesis
REACT_160086Regulation of actin dynamics for phagocytic cup formation
REACT_19230Role of Abl in Robo-Slit signaling
REACT_19351Signaling by Robo receptor
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