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MGP000012

UniProt Annotations

Entry Information
Gene Nameamine oxidase, copper containing 1
Protein EntryAOC1_HUMAN
UniProt IDP19801
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P19801-1; Sequence=Displayed; Name=2; Synonyms=DAO2; IsoId=P19801-2; Sequence=VSP_055190; Note=Ref.3 (AAB60381) sequence is in conflict in position: 632:A->R. {ECO:0000305};
Catalytic ActivityHistamine + H(2)O + O(2) = (imidazol-4- yl)acetaldehyde + NH(3) + H(2)O(2).
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:19764817}; Note=Binds 2 calcium ions per subunit. {ECO:0000269|PubMed:19764817};
CofactorName=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000269|PubMed:19764817}; Note=Binds 1 copper ion per subunit. {ECO:0000269|PubMed:19764817};
CofactorName=L-topaquinone; Xref=ChEBI:CHEBI:79027; Evidence={ECO:0000269|PubMed:19764817}; Note=Contains 1 topaquinone per subunit. {ECO:0000269|PubMed:19764817};
FunctionCatalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
MiscellaneousInhibited by amiloride in a competitive manner. {ECO:0000250}.
PtmTopaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
Sequence CautionSequence=AAA58358.1; Type=Frameshift; Positions=266, 284, 328, 494, 497, 514, 707, 729; Evidence={ECO:0000305};
SimilarityBelongs to the copper/topaquinone oxidase family. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space.
SubunitHomodimer; disulfide-linked. {ECO:0000269|PubMed:19764817}.
Tissue SpecificityPlacenta and kidney.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/abp1/";
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