MGP Database

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MGP000016

Ontology/Pathway Information

Entrez Gene ID31
Gene Nameacetyl-CoA carboxylase alpha
Gene Symbol ACACA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0015629 IDA:HPACactin cytoskeleton
GO:0005737 IDA:HPACcytoplasm
GO:0005829 ISS:UniProtKBCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005730 IDA:HPACnucleolus
GO:0003989 ISS:UniProtKBFacetyl-CoA carboxylase activity
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004075 IEA:UniProtKB-ECFbiotin carboxylase activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0006084 ISS:UniProtKBPacetyl-CoA metabolic process
GO:0006768 TAS:ReactomePbiotin metabolic process
GO:0006853 TAS:ReactomePcarnitine shuttle
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0006633 ISS:UniProtKBPfatty acid biosynthetic process
GO:0055088 IEA:EnsemblPlipid homeostasis
GO:0035338 TAS:ReactomePlong-chain fatty-acyl-CoA biosynthetic process
GO:2001295 IEA:UniProtKB-UniPathwayPmalonyl-CoA biosynthetic process
GO:0044268 IEA:EnsemblPmulticellular organismal protein metabolic process
GO:0031325 TAS:ReactomePpositive regulation of cellular metabolic process
GO:0051289 ISS:UniProtKBPprotein homotetramerization
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0001894 IEA:EnsemblPtissue homeostasis
GO:0019432 TAS:ReactomePtriglyceride biosynthetic process
GO:0006766 TAS:ReactomePvitamin metabolic process
GO:0006767 TAS:ReactomePwater-soluble vitamin metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147904Activation of gene expression by SREBF (SREBP)
REACT_11153Biotin transport and metabolism
REACT_2122ChREBP activates metabolic gene expression
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_1319Fatty Acyl-CoA Biosynthesis
REACT_11082Import of palmitoyl-CoA into the mitochondrial matrix
REACT_1505Integration of energy metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors
REACT_147797Regulation of cholesterol biosynthesis by SREBP (SREBF)
REACT_1190Triglyceride Biosynthesis
SMP Pathway Links
SMP IDDescription
SMP00456Fatty Acid Biosynthesis
SMP00196Leigh Syndrome
SMP00198Malonic Aciduria
SMP00502Malonyl-coa decarboxylase deficiency
SMP00201Methylmalonic Aciduria Due to Cobalamin-Related Disorders
SMP00558Primary hyperoxaluria II, PH2
SMP00016Propanoate Metabolism
SMP00334Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
SMP00212Pyruvate Dehydrogenase Complex Deficiency
SMP00559Pyruvate kinase deficiency
SMP00060Pyruvate Metabolism
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